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Physical & Chemical properties

Partition coefficient

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
09/2017 to 2017-12-21
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
Version / remarks:
1995-07-27
Qualifier:
according to guideline
Guideline:
EU Method A.8 (Partition Coefficient - Shake Flask Method)
Version / remarks:
2008
Qualifier:
according to guideline
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Version / remarks:
August 1996
GLP compliance:
no
Type of method:
flask method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch 6716-16E
- Expiration date of the lot/batch: Retest date: 2018-10-23
- Purity test date: 2016-11-17


STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: 20 °C +/- 5°C, in the desiccator in the dark
- Stability under test conditions: stable
- Solubility and stability of the test substance in the solvent/vehicle: soluble in water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
-1.51
Temp.:
20 °C
pH:
ca. 1.8
Details on results:
The partition coefficient was calculated based on the results of the analytical determination. The test item content was determined by HPLC. The log Pow was calculated for each run.
The difference between the three different test variants at each pH value was less than the given +/- 0.3 log units. Therefore, the study can be considered to be valid.
According to this study the logarithmic partition coefficient (n octanol/water) of the test item was determined to be -1.51 using the shake flask method at 20 °C.
Conclusions:
log pow = -1.51
Executive summary:

The purpose of the guideline study was to determine the partition coefficient of oxaceprol between n-octanol and water using the shake flask method.

The partition coefficient was calculated based on the results of the analytical determination. The content of oxaceprol was determined by HPLC. The log Pow was calculated for each run.

The difference between the three different test variants at each pH value was less than the given ± 0.3 log units. Therefore, the study can be considered to be valid.

According to this study the logarithmic partition coefficient (n‑octanol/water) of the test item was determined to be -1.51 using the shake flask method at 20 °C.

Description of key information

log pow = -1.51

Key value for chemical safety assessment

Log Kow (Log Pow):
-1.51
at the temperature of:
20 °C

Additional information

In a guideline study the logarithmic partition coefficient (n-octanol/water) of the test item was determined to be -1.51 using the shake flask method at 20 °C. A calculated value was close to the value determined in that experimental study.