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EC number: 232-152-0 | CAS number: 7789-24-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988-12-28 to 1989-01-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Version / remarks:
- February 24, 1987
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPP 81-1 (Acute Oral Toxicity)
- Version / remarks:
- November 1984
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Lithium fluoride
- EC Number:
- 232-152-0
- EC Name:
- Lithium fluoride
- Cas Number:
- 7789-24-4
- Molecular formula:
- FLi
- IUPAC Name:
- lithium(1+) fluoride
- Test material form:
- solid
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- lot No.of test material: Lot 129, Drums 1 - 10
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Taconic Farms, Germantown, New York
- Weight at study initiation: 201 - 291 g
- Fasting period before study: overnight prior to dosing
- Housing: the animals were individually housed in stainless steel suspended rat cages
- Diet: Purina Laboratory Rodent Chow 5001 ad libitum
- Water: tap water ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature: 66 °F - 73 °F
- Humidity: 24 % to 63 %
- Photoperiod: 12 hour fluorescent light and 12 hour dark cycle
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 25 % (weight/volume) solution with tap water - Doses:
- males: 500, 700, 1000 mg/kg
females: 500, 1000, 2000 mg/kg - No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: the animals were observed for mortality and clinical signs at 0.5, 1, 2, 3, 4 and 6 hours on the day of dosing and twice daily thereafter for thirteen days; on day 14 they were observed once. Body weights were taken on days 0, 7 and 14 of the study
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, organ weights.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 608 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 448 - <= 768
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 004 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 472 - <= 1 535
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 706 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- ca. 453 - <= 959
- Mortality:
- Mortality in males
500 mg/kg bw dose group - 1/5
700 mg/kg bw dose group - 4/5
1000 mg/kg bw dose group - 5/5
Mortality in females
500 mg/kg bw dose group - 1/5
1000 mg/kg bw dose group - 2/5
2000 mg/kg bw dose group - 5/5 - Clinical signs:
- other: Clinical signs commonly observed during the study included ataxia, tremors, diarrhea, abdominogenital staining, chromorhinorrhea and chromodacryorrhea. The onset of signs began approximately 1 hour after dosing and continued to be observed until day 6 of
- Gross pathology:
- Gross internal necropsy findings observed in decedents included blood in the intestines of several rats, one of which also had a stomach which was distended with gas. All surviving animals appeared normal at necropsy.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- Under the conditions of the study, a male LD50 value of 608 mg/kg bw, a female LD50 value of 1004 mg/kg bw, and a combined LD50 value of 706 mg/kg bw were obtained when orally administered as a 25 % (weight/volume) solution in tap water.
- Executive summary:
Groups of Sprague-Dawley rats consisting of five males and/or five females were orally administered graded dosages of the test substance as a 25 % (weight/volume) solution in tap water by gavage according to OECD Guideline 401. Males were administered with 500, 700 and 1000 mg/kg bw. Females were administered with 500, 700 and 2000 mg/kg bw.
Mortality occurred in all dose groups. By male rats in dose groups 500, 700 and 1000 mg/kg bw out of 5 rats per dose group 1, 4, 5 rats died respectively. By female rats in dose groups 500, 1000 and 2000 mg/kg bw out of 5 rats per dose group 1, 2, 5 rats died respectively. The predominant clinical signs were ataxia, tremors, diarrhea, abdominogenital staining, chromorhinorrhea and chromodacryorrhea. Most signs of toxicity subsided by day 6 of the study. All surviving animals gained weight by day 14 of the study.
Gross internal necropsy findings observed in decedents included blood in the intestines of several rats, one of which also had a stomach which was distended with gas. Animals which survived treatment and were sacrificed on day 14 appeared normal when necropsied.
Under the conditions of the study, a male LD50 value of 608 mg/kg bw, a female LD50 value of 1004 mg/kg bw, and a combined LD50 value of 706 mg/kg bw were obtained when orally administered as a 25 % (weight/volume) solution in tap water.
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