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Diss Factsheets
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EC number: 906-936-4 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Biodegradation in water and sediment: simulation tests
Administrative data
- Endpoint:
- biodegradation in water and sediment: simulation testing, other
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Study period:
- 2015 or prior
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Justification for type of information:
- Read across is based on the category approach. Please refer to attached category document.
Data source
Reference
- Reference Type:
- publication
- Title:
- Biodegradation screening of chemicals in an artificial matrix simulating the water-sediment interface
- Author:
- E Baginska, A HaiB, K Kummerer
- Year:
- 2 015
- Bibliographic source:
- Chemosphere 119: 1240-1246
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 308 (Aerobic and Anaerobic Transformation in Aquatic Sediment Systems)
- Principles of method if other than guideline:
- This word was based on OECD guideline 308. Increased reproducibility was achieved by creating an artificial and standardized medium, based on the existing OECD guidelines OECD 302C, 301D, and 218.
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2'-oxydiethanol
- EC Number:
- 203-872-2
- EC Name:
- 2,2'-oxydiethanol
- Cas Number:
- 111-46-6
- Molecular formula:
- C4H10O3
- IUPAC Name:
- 2,2'-oxydiethanol
Constituent 1
- Specific details on test material used for the study:
- Purchased from Carl Roth, Germany
- Radiolabelling:
- no
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- artificial sediment
- Details on source and properties of sediment:
- Artificial sediment (OECD guideline 218 (OECD, 2004)) was composed of kaolin clay (5% dry weight), quartz sand (grain size 0.8–0.2 mm; 92% dry weight), sphagnum moss peat (2% dry weight), and calcium carbonate (<0.1% dry weight).
- Details on inoculum:
- Inoculum (OECD guideline 302C (OECD, 1981)) prepared from mixed sources of surface water and sediment as well as effluent from sewage treatment plant. Since the low bacterial density was suspected in WST the mineral medium composition, which contained of mineral salts, trace elements, and growth factors, was based on the OECD guideline 301D (OECD, 1992)) where low bacterial density is used.
- Duration of test (contact time):
- 28 d
Initial test substance concentrationopen allclose all
- Initial conc.:
- 64.22 mg/L
- Based on:
- test mat.
- Initial conc.:
- 32 mg/L
- Based on:
- test mat.
- Parameter followed for biodegradation estimation:
- other: Pressure change in closed vessel
- Details on study design:
- Each of the series were placed in glass bottles (1 L) equipped with two septum sealed bottle nozzles . Aniline and test compound concentration in all series was 40 mg/L expressed as theoretical oxygen demand (ThOD). All assays were incubated in the dark at 20 degrees C in closed vessels. Test duration was 28 d. The water phase in the bottles was stirred to improve water exchange between water and sediment phase but not vigorously to avoid disturbance of the sediment. Water to sediment ratio was 1:5. During the experiment pressure change inside the vessels are measured by pressure sensors using OxiTop system (WTW Weilheim, Germany).
Reference substanceopen allclose all
- Reference substance:
- aniline
- Remarks:
- 4, 10, 20, 40 mg/l; 99.96 mg/l
- Reference substance:
- diethylene glycol
- Remarks:
- 80.28 mg/l
- Reference substance:
- other: sodium acetate
- Remarks:
- 20.16 mg/l
Results and discussion
- Test performance:
- Aniline in all four concentrations achieved similar
rates and levels of biodegradation; 64 ± 17%; 80 ± 4%; 62 ± 10%;
68 ± 84% for 40, 20, 10, and 4 mg L1 respectively (Supplementary
material Fig. S1). With increasing concentration, the measurement
was more stable and clear biodegradation curves were observed.
With the exception of the highest concentration, the lower the concentration the higher the standard deviation was observed. Best values in regards to standard deviation were obtained at a test concentration of 20 mg/l aniline which corresponds to a ThOD of 48.2 mg/l. Optimum test substance concentration was therefore decided to be 40 mg/l in terms of ThOD.
% Degradation
- % Degr.:
- 77
- Parameter:
- other: based on pressure development from CO2
- Sampling time:
- 28 d
Applicant's summary and conclusion
- Conclusions:
- The WST provides testing conditions (presence of water–sediment interface) that are more complex than those in standardized screening tests, where only biodegradation performed by bacteria suspended in water phase is taken into account. Under the conditions in this study, 77 and 78% degradation of 64.22 and 32 mg/l DEG, respectively, was observed in 28 days, with lag times of 4 and 5 days.
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