Registration Dossier
Registration Dossier
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EC number: 204-420-7 | CAS number: 120-72-9
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 962
- Report date:
- 1962
- Reference Type:
- review article or handbook
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Penetration of rabbit skin is estimated by a technique losely akin to the one-day cuff method of Draize and associates, using groups of four male albino New Zealand rabbits weighing 2.5-3.5 kg.
- GLP compliance:
- no
Test material
- Reference substance name:
- Indole
- EC Number:
- 204-420-7
- EC Name:
- Indole
- Cas Number:
- 120-72-9
- Molecular formula:
- C8H7N
- IUPAC Name:
- 1H-indole
- Test material form:
- solid
1
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- 4 rabbits were tested.
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- ca. 790 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- Category 3 based on GHS criteria
- Conclusions:
- H311 Acute tox dermal cat 3
- Executive summary:
LD 50 dermal rat = 790 mg/kg bw
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