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EC number: 401-100-0 | CAS number: 109037-78-7 TILCOM CA35; TILCOM IA10; TYTAN AP 100; TYTAN CA 100; TYTAN CX 35; TYZOR IAM
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Hydrolysis
Administrative data
Link to relevant study record(s)
- Endpoint:
- hydrolysis
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1 Jun. 2013 - 5 Mar. 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 111 (Hydrolysis as a Function of pH)
- Version / remarks:
- 2004
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Remarks:
- two hydrolytic products – ethanol and 2-propanol – were selected as targets to probe the reaction extent. The targeted hydrolysis products were detected by headspace GC/MS-headspace technique
- Details on sampling:
- Weigh 0.015 g sample into 20 mL headspace vial. Reduce exposure to air when transferring the sample. After adding 1 mL of regent, cap the headspace vial immediately and shake rigorously.
- Buffers:
- HCl solution (pH=4), water (pH=7), NaOH solution (pH=10)
- Duration:
- 60 min
- pH:
- 4
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.75 g/L
- Duration:
- 60 min
- pH:
- 7
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.75 g/L
- Duration:
- 60 min
- pH:
- 10
- Temp.:
- 25 °C
- Initial conc. measured:
- 0.75 g/L
- Number of replicates:
- not specified
- Positive controls:
- not specified
- Negative controls:
- not specified
- Preliminary study:
- Water was added into the Test Substance to initiate the hydrolysis. 30 minutes after the reaction began, the aliquots of the solution was injected into
GC/MS for composition analysis. - Transformation products:
- yes
- No.:
- #1
- No.:
- #2
- No.:
- #3
- No.:
- #4
- No.:
- #5
- Details on hydrolysis and appearance of transformation product(s):
- The solution immediately became cloudy and white precipitation forms when water was added into the Test Substance, indicating the rapid hydrolysis behavior of the Test Substance.
- Key result
- pH:
- 4
- Temp.:
- 25 °C
- DT50:
- ca. 10 min
- Type:
- not specified
- Key result
- pH:
- 7
- Temp.:
- 25 °C
- DT50:
- ca. 15 min
- Type:
- not specified
- Key result
- pH:
- 10
- Temp.:
- 25 °C
- DT50:
- ca. 10 min
- Type:
- not specified
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The components in the Test Substance aqueous solution were identified, and two were further confirmed as the hydrolytic products – ethanol and 2-propanol.
The half time of reaction was estimated to be less than 10 minutes under acidic/basic, and less than 15 minutes under neutral condition. - Executive summary:
The hydrolysis behavior of Butyl (dialkyloxy(dibutoxyphosphoryloxy))titanium(trialkyloxy)titanium phosphate (EC
no. 401-100-0, the Test Substance) at 25°C in the normally found environment conditions was observed and determined in the study. By detecting the main degradation substances qualitatively as well as quantitatively, it was safely concluded
that the half-life time at 25°C of the Test Substance was:
pH 4 ≤ 10 min
pH 7 ≤ 15 min.
pH 10 ≤ 10 min.
According to formulation of the Test Substance, the degraded substances could be estimated as inorganic part as titanium and organic part. The observation of inorganic part indicated the hydrolysis behavior of the Test Substance when the diluent became
cloudy. The organic part, identified by GC/MS, contained simple alcohols (ethanol, 2-propanol and 1-butanol), alkyl phosphates and traces of hydrocarbons as impurities. Among the hydrolysis products, ethanol and 2-propanol were chosen for quantification with respect to hydrolysis time.
Reference
Description of key information
The half-life time at 25°C of the Test Substance is:
pH 4 ≤ 10 min
pH 7 ≤ 15 min.
pH 10 ≤ 10 min.
Key value for chemical safety assessment
- Half-life for hydrolysis:
- 15 min
- at the temperature of:
- 25 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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