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Diss Factsheets
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EC number: 946-253-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1976
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- Study performed equivalent or similar to OECD 402, but pre-GLP.
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
- Limit test:
- yes
- Specific details on test material used for the study:
- TSCA-CAS No.: 8008-79-5
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- No data available
- Duration of exposure:
- No data
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 10 (one dose, unspecified sex)
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs and skin irritation - Statistics:
- Not relevant
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 3/10 animals died at 5000 mg/kg bw
- Mortality:
- Mortality was seen in 3 out of 10 animals. The animals died on day 2,4 and 6.
- Clinical signs:
- other: Hypothermia and ataxia was observed in 2 out of 3 rabbits that died. Moderate redness and edema was seen in all test animals.
- Gross pathology:
- No data available
- Other findings:
- No data available
- Interpretation of results:
- other: Not classified
- Remarks:
- Based on CLP criteria
- Conclusions:
- Under the conditions of this test, an LD50 greater than 5000 mg/kg bw was found. Based on this result, the test substance does not need to be classified for acute dermal toxicity in accordance with the criteria outlined in Annex I of 1272/2008/EC (CLP).
- Executive summary:
A dermal toxicity test was performed on 10 rabbits according to a method similar to OECD402. A single dose of 5000 mg/kg bw was used. Mortality, clinical signs and skin irritation were observed for 14 days.
Three out of 10 animals died during the observation period on day 2, 4 and 6. Hypothermia and ataxia was observed in 2/3 animals which died. Moderate redness and edema was observed in all animals.
In conclusion, an LD50 of >5000 mg/kg bw was established and therefore the test substance does not need to be classified for acute dermal toxicity in accordance to the criteria outlined in Annex I of 1272/2008/EC (CLP).
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 976
- Report date:
- 1976
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Principles of method if other than guideline:
- A dermal toxicity test was performed on 10 rabbits according to a method similar to OECD402. A single dose of 5000 mg/kg bw was used. Mortality, clinical signs and skin irritation were observed for 14 days.
- GLP compliance:
- no
- Remarks:
- pre-GLP
Test material
- Reference substance name:
- Essential oil of Spearmint obtained from the aerial part of Mentha spicata and/or Mentha cardiaca (Lamiaceae) obtained by distillation
- EC Number:
- 946-253-9
- Molecular formula:
- Not applicable
- IUPAC Name:
- Essential oil of Spearmint obtained from the aerial part of Mentha spicata and/or Mentha cardiaca (Lamiaceae) obtained by distillation
- Details on test material:
- - Name of test material (as cited in study report): Spearmint oil
- Physical state: liquid
- Purity: no data
- Lot/batch No.: Confidential information
1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): not specified
- Concentration (if solution): 5000 mg/kg bw undiluted test substance - Duration of treatment / exposure:
- not specified
- Observation period:
- 14 days
- Number of animals:
- 10
- Details on study design:
- TEST SITE
- Area of exposure: not specified
- % coverage: not specified
- Type of wrap if used: not specified
REMOVAL OF TEST SUBSTANCE
- Washing (if done): not specified
- Time after start of exposure: not specified
OBSERVATION TIME POINTS
Mortality, clinical signs and skin irritation were observed for 14 days.
SCORING SYSTEM:
- Method of calculation: not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other: Redness and edema
- Basis:
- other: All 10 animals
- Time point:
- other: Not specified
- Remarks on result:
- other: moderate redness and edema were observed in all animals
- Irritant / corrosive response data:
- Moderate redness and edema were observed in all animals.
- Other effects:
- Mortality was seen in 3 out of 10 animals. The animals died on day 2,4 and 6. Hypothermia and ataxia was observed in 2 out of 3 rabbits that died.
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 2 (irritant)
- Remarks:
- Based on CLP criteria
- Conclusions:
- Under the conditions of the test, undiluted Spearmint oil is considered to cause skin irritation in rabbits. Based on this, the substance should be classified for skin irritation in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
A dermal toxicity test was performed on 10 rabbits according to a method similar to OECD402. A single dose of 5000 mg/kg bw was used. Mortality, clinical signs and skin irritation were observed for 14 days.
Moderate redness and edema was observed in all animals. Under the conditions of the test, undiluted Spearmint oil is considered to cause skin irritation in rabbits. Based on this, the substance should be classified for skin irritation in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
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