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EC number: 272-028-3 | CAS number: 68649-42-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from IUCLID data set
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Acute dermal toxicity study in rabbits
- Author:
- Toxic Substances Control Act Test Submissions (TSCATS)
- Year:
- 2 006
- Bibliographic source:
- United States Environmental Protection Agency (EPA) 2006
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute dermal toxicity study of Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts (89-92 %) in rabbits
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- EC Number:
- 272-028-3
- EC Name:
- Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts
- Cas Number:
- 68649-42-3
- Molecular formula:
- C28H60O4P2S4Zn
- IUPAC Name:
- Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Test material form:
- liquid
- Details on test material:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): Dialkyl(C1-C14)dithiophosphoric acid, zinc salt
- Common name: Phosphorodithioic acid, O,O–di–C1–14–alkyl esters, zinc salts
- Molecular formula: C28H60O4P2S4Zn
- Molecular weight: 716.38 g/mol
- Smiles notation: [Zn+2].CCCCCCCOP(=S)([S-])OCCCCCCC.CCCCCCCOP(=S)([S-])OCCCCCCC
- InChl: 1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
- Substance type: Organic
- Physical state: liquid
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- not specified
- Duration of exposure:
- single
- Doses:
- 200 and 3160 mg/kg bw
- No. of animals per sex per dose:
- Total: 8
200 mg/kg bw: 2 male, 2 female
3160 mg/kg bw: 2 male, 2 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: on day fist, 7 and on 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight and gross pathology were examined. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 3 160 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No effect on survival
- Mortality:
- No mortality were observed in treated rabbits at 3160 mg/kg bw
- Clinical signs:
- other: Hypo-activity were observed in treated rabbits at 3160 mg/kg bw. The observed reaction was subside within 4 hours.
- Gross pathology:
- No gross pathological changes were observed in treated rabbits.
- Other findings:
- Moderate irritation were observed at 200 mg/kg bw and severe irritation at 3160 mg/kg bw in treated rabbits.
Red well-defined erythema and sever edema at 24 hours, moderate to severe desquamation and fissuring at day 7 and mild to moderate desquamation at day 14 were observed in 200 mg/kg bw treated rabbits.
Beet red erythema, sever edema and second degree burns at 24 hour, escharosis fissuring and hemorrhaging at day 7 and escharosis, necrosis and sever desquamation at day 14 were observed in 3160 mg/kg bw treated rabbits.
Any other information on results incl. tables
Acute Dermal Toxicity Study – Albino Rabbits
Dose Level (mg/kg) |
Animal number |
Individual Body Weight (Kg) |
Number Dead/Number Tested |
Percent Dead |
||
Test Day Number: |
||||||
0 |
7 |
14 |
||||
200 |
1-M 2-M 3-F 4-F
|
3.00 3.30 3.20 3.42
|
3.00 3.20 3.18 3.50 |
3.12 3.30 3.38 3.54 |
0/4 |
0 |
3160 |
5-M 6-M 7-F 8-F |
2.92 3.08 3.06 3.68 |
2.82 2.64 2.18 2.28 |
3.10 2.78 2.24 2.04 |
0/4 |
0 |
NOTE: The Test Skin Sites Of all Rabbits Were Abraded.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be 3160 mg/kg bw when male and female rabbits were exposed with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts on abraded skin.
- Executive summary:
In a acute dermal toxicity study,male and female rabbits were treated with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts in the concentration of200 and 3160 mg/kg bw applied onabraded skinand observed for 14 days.No mortality were observed in treated rabbits at 3160 mg/kg bw. Hypo-activity were observed in treated rabbits at 3160 mg/kg bw. The observed reaction was subside within 4 hours. In one male rabbit weight loss was observed during first week of treatment at 3160 mg/kg bw, which was resumed normal during second week. One female rabbit lost weight throughout 14 day of treatment. Moderate irritation were observed at 200 mg/kg bw and severe irritation at 3160 mg/kg bw in treated rabbits. Red well-defined erythema and sever edema at 24 hours, moderate to severe desquamation and fissuring at day 7 and mild to moderate desquamation at day 14 were observed in 200 mg/kg bw treated rabbits. Beet red erythema, sever edema and second degree burns at 24 hour, escharosis fissuring and hemorrhaging at day 7 and escharosis, necrosis and sever desquamation at day 14 were observed in 3160 mg/kg bw treated rabbits. No gross pathological changes were observed in treated rabbits. Therefore,LD50 was considered to be3160 mg/kg bw when male and female rabbits were exposed with Phosphorodithioic acid, O,O-di-C1-14-alkyl esters, zinc salts on abraded skin.
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