Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 218-441-4 | CAS number: 2152-64-9
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer- reviewed journal
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety Assessment of Isoparaffins as Used in Cosmetics
- Author:
- Wilbur Johnson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, Daniel Liebler, James G. Marks Jr., Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen.
- Year:
- 2 012
- Bibliographic source:
- International Journal of Toxicology, vol. 31, suppl 3 : pp. 269S-295S, 2012
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as below
- Principles of method if other than guideline:
- Acute oral toxicity in mice by using 13475-82-6 (Isododecane).
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2,4,6,6-Pentamethylheptane/
- Cas Number:
- 13475-82-6
- Molecular formula:
- C12H26
- IUPAC Name:
- 2,2,4,6,6-Pentamethylheptane/
- Details on test material:
- - Name of test material (as cited in study report): 2,2,4,6,6-Pentamethylheptane (Isododecane)
- Molecular formula (if other than submission substance): C12H26
- Molecular weight (if other than submission substance): 170.337 g/mole
- Substance type: Organic
- Physical state: No data
Purity Approx 85%
- Impurities (identity and concentrations): Approx 15%
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (as cited in study report): 2,2,4,6,6-Pentamethylheptane (Isododecane)
- Molecular formula (if other than submission substance): C12H26
- Molecular weight (if other than submission substance): 170.337 g/mole
- Substance type: Organic
- Physical state: No data
Purity Approx 85%
- Impurities (identity and concentrations): Approx 15%
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- olive oil
- Remarks:
- 10 %
- Details on oral exposure:
- not specified
- Doses:
- 2000 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not specified
- Details on study design:
- not specified
- Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No moratlity observed
- Mortality:
- No mortality was observed at 2000 mg/kg bw.
- Clinical signs:
- not specified
- Body weight:
- not specified
- Gross pathology:
- not specified
- Other findings:
- not specified
Any other information on results incl. tables
Table: Acute Oral Toxicity Study onIsododecane
Material |
Predominant carbon length |
Animals |
Result
|
Isododecane (10% Olive oil) |
C12 |
5 Mice |
LD50 >2 g/kg |
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- LD50 was considered to be > 2000 mg/kg when mice was treated with Isododecane orally.
- Executive summary:
The acute oral toxicity study was conducted by using Isododecane in 5 mice in the concentration of 2000 mg/kg bw orally in 10%Olive oil.No mortality was observed at 2000 mg/kg bw. Therefore, LD50 was considered to be > 2000 mg/kg when mice were treated with Isododecane orally.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
