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EC number: 212-220-6 | CAS number: 770-12-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- from 1997-05-16 to 1997-06-26
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl phosphorodichloridate
- EC Number:
- 212-220-6
- EC Name:
- Phenyl phosphorodichloridate
- Cas Number:
- 770-12-7
- Molecular formula:
- C6H5Cl2O2P
- IUPAC Name:
- phenyl dichlorophosphate
- Test material form:
- solid
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Direct dispersion in water. An amount of test material (200 mg) was dispersed in reconstituted water and the volume adjusted to 2 litres to give the 100 mg/l test concentration from which dilutions were made to give the remainder of the test series of 1.0, 1.8, 3.2, 5.6, 10, 18,32 and 56 mg/i.
Test organisms
- Test organisms (species):
- Daphnia magna
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Post exposure observation period:
- No
Test conditions
- Hardness:
- 270 mg/L as CaCO3
- Test temperature:
- No data
- pH:
- 7.8 ± 0.2 adjusted if necessary with NaOH or HCl
- Dissolved oxygen:
- Do data
- Salinity:
- Not applicable
- Conductivity:
- < 5µS /cm
- Nominal and measured concentrations:
- range finding study: 0.1, 1, 10 and 100 mg/L (Nominal)
Definitive test: 1.0, 1.8, 3.2, 5.6, 10, 18, 32, 56 and 100 mg/L (Nominal) - Details on test conditions:
- TEST SYSTEM
- Test vessel: 250 mL containing 200 mL of test solution
- Aeration: No auxiliary aeration
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): 1 in the range finding test and 2 in the definitive test
- No. of vessels per control (replicates): 1 in the range finding test and 2 in the definitive test
TEST MEDIUM / WATER PARAMETERS
Stock Solutions
a) CaCI2.2H2O: 11.76 g/l
b) MgSO4.7H2O: 4.93 g/l
c) NaHCO3: 2.59 g/l
d) KCI: 0.23 g/l
ii) Preparation
25 ml of each of solutions a-d were added to each litre (final volume) of deionised water (conductivity < 5 JlS cm-1) pH equal to 7.8 :t 0.2, adjusted (if necessary) with NaOH or HCI.
The reconstituted water was aerated until the dissolved oxygen concentration was approximately air-saturation value.
The reconstituted water has an approximate theoretical total hardness of 270 mg/l as CaCO3"
RANGE-FINDING STUDY
- Test concentrations: 0.1, 1, 10 and 100 mg/L
- Results used to determine the conditions for the definitive study:
0% mortality at 1 mg/L and 100% mortality at 10 and 100 mg/L after 48 exposure. 0% mortality at 10 mg/L after 24h exposure. - Reference substance (positive control):
- no
Results and discussion
Effect concentrationsopen allclose all
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 7.4 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 3.2 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Details on results:
- - Mortality of control: No mortality observed
- Other adverse effects control:
- Observations made on the test media throughout the study showed the control, 1.0, 1.8, 3.2, 5.6, 10, 18, 32, 56 and 100 mg/l test concentrations to be clear, colourless solutions. - Results with reference substance (positive control):
- No applicable
Any other information on results incl. tables
Range finding
Concentration (mg/L) |
Cumulative mortality (Initial population = 10) |
|
24 hours |
48 hours |
|
Control |
0 |
0 |
0.10 |
0 |
0 |
1.0 |
0 |
0 |
10 |
0 |
10 |
100 |
10 |
10 |
Definitive study
Nominal concentration (mg/L) |
Cumulative immobilized Daphnia (Initial population: 10 per replicate) |
|||||||
24 hours |
48 hours |
|||||||
R1 |
R2 |
Total |
% |
R1 |
R2 |
Total |
% |
|
Control |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1.0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1.8 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
3.2 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
5.6 |
0 |
0 |
0 |
0 |
2 |
3 |
5 |
25 |
10 |
0 |
0 |
0 |
0 |
8 |
9 |
17 |
85 |
18 |
0 |
0 |
0 |
0 |
10 |
9 |
19 |
95 |
32 |
0 |
0 |
0 |
0 |
10 |
10 |
20 |
100 |
56 |
7 |
5 |
12 |
60 |
10 |
10 |
20 |
100 |
100 |
10 |
10 |
20 |
100 |
10 |
10 |
20 |
100 |
R1: Repliacte 1 and R2: replicate 2
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- The phenyl dichlorophospohate was considered to be toxic to aquatic invertebrate according to GHS UN criteria (EC50 48h = 7.4 mg/L) but not classified according to CLP criteria.
- Executive summary:
The acute toxicty on aquatic invertebrates of phenyl dichlorophosphine was evaluated on Daphnia magna according to OECD 202 test guideline.
The 48h-EC50 was determinated to be 7.4 mg/L.
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