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Diss Factsheets
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EC number: 202-595-4 | CAS number: 97-62-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 27.06.2016 - 01.07.2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 6.45 g/L
- Conc. based on:
- test mat.
- Loading of aqueous phase:
- 50 g/L
- Incubation duration:
- 72 h
- Temp.:
- 20 °C
- pH:
- 6
- Remarks on result:
- other: Mean of 2 replicate measurements
- Details on results:
- The method validation showed acceptable results for all parameters addressed. The test results are therefore considered valid.
- Conclusions:
- The water solubility was determined to be 6.45 g/L (20°C, pH 6.0).
- Executive summary:
In the current study the water solubility of the test item was determined according to OECD guideline 105 and Council Regulation (EC) No. 260/2014, Method A.6.
The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C. The analytical method (HPLC-DAD, external standard) was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility was determined to be 6.45 g/L (20°C, pH 6.0).
Reference
The details of the results are:
pre-incubation time (h) | replicate | concentration (g/L) | mean concentration (g/L) |
24 | 1 | 6.54 | 6.5 |
2 | 6.45 | ||
48 | 1 | 6.52 | 6.49 |
2 | 6.46 | ||
72 | 1 | 6.37 | 6.38 |
2 | 6.38 |
The mean water solubility over 24 -72h is 6.45 with deviation 1.9 %
Description of key information
The water solubility was determined to be 6.45 g/L (20°C, pH 6.0).
Key value for chemical safety assessment
- Water solubility:
- 6.45 g/L
- at the temperature of:
- 20 °C
Additional information
There is one study available assessing the water solubility of the test item according to OECD guideline 105 and Council Regulation (EC) No. 260/2014, Method A.6. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C. The water solubility was 6.45 g/L (20°C, pH 6.0).
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