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Diss Factsheets
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EC number: 911-295-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- August / September 1986
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- To evaluate the eye irritation potential for the test substance, the right eyes of 4 animals were exposed to the test item for 24 hours. Left eye served as control. The eye's animals were examinated 24 hours and 7 days after exposure, and the score of irritation were calculated.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- reaction mass of decyl acrylate and octyl acrylate
- EC Number:
- 911-295-9
- Molecular formula:
- C11H20O2 and C13H24O2
- IUPAC Name:
- reaction mass of decyl acrylate and octyl acrylate
- Test material form:
- liquid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- no data
- Duration of treatment / exposure:
- 24 hours
- Observation period (in vivo):
- at 24 hours and day 7 after exposure.
- Number of animals or in vitro replicates:
- 4
- Details on study design:
- Right eyes of animals were exposed to the test item. Left eye served as control.
Score of each effect were noted, eyes are not rinsed.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- conjunctivae score
- Remarks:
- (redness)
- Basis:
- mean
- Remarks:
- 4 rabbits
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: individual scores: 1-1-1-1
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Remarks:
- 4 rabbits
- Time point:
- 24 h
- Score:
- 1
- Max. score:
- 3
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- other: individual scores:1-1-1-1
- Irritation parameter:
- iris score
- Basis:
- mean
- Remarks:
- 4 rabbits
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 2
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Remarks:
- 4 rabbits
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- All four animals exhibited slight conjunctival irritation, four exhibited iridial changes and two exhibited slight corneal changes at 14 hours. Except for slight discharge noted in one animal, all animals were free of ocular abnormalities by Day 7.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Test substance produced a mild reversible ocular irritation.
- Executive summary:
To evaluate the eye irritatiion potential fo the test substance, the right eyes of 4 animals were exposed to the test item for 24 hours. Left eye served as control. The eye's animals were examinated 24 hours and 7 days after exposure, and the score of irritation were calculated. Slight effects were observed on the conjunctivae (redness and chemosis). These effects were reversible within 7 days. However no effect was observed on iritis and cornea. Based on the results, the test substance produced a mild reversible ocular irritation.
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