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EC number: 246-758-8 | CAS number: 25251-42-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data from secondary source
Data source
Referenceopen allclose all
- Reference Type:
- other: Authoritative database
- Title:
- Acute dermal toxicity for CAS NO: 107-64-2
- Author:
- IFA GESTIS
- Year:
- 2 017
- Bibliographic source:
- GESTIS SUBSTANCE Database (information system in hazardous substance of the Berufsgenossenscheftn), 2017
- Reference Type:
- secondary source
- Title:
- Initial Submission: Letter from Monsanto Co to USEPA regarding Cyanuric Acid Crude with Attachments and Cover Letter Dated 072392
- Author:
- NTRL
- Year:
- 1 992
- Bibliographic source:
- NTRL report, OTS0538650, 1992
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- An acute dermal toxicity study of Cyanuric acid was carried out on rabbits
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- Cyanuric acid
- EC Number:
- 203-618-0
- EC Name:
- Cyanuric acid
- Cas Number:
- 108-80-5
- Molecular formula:
- C3H3N3O3
- IUPAC Name:
- 1,3,5-Triazin-2,4,6-triol
- Details on test material:
- - Name of test material: Cyanuric acid
- IUPAC name: 1,3,5-Triazinane-2,4,6-trione
- Molecular formula: C3H3N3O3
- Molecular weight: 129.075 g/mol
- Substance type: Organic
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: Cyanuric acid
- IUPAC name: 1,3,5-Triazinane-2,4,6-trione
- Molecular formula: C3H3N3O3
- Molecular weight: 129.075 g/mol
- Substance type: Organic
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Details on test animal
TEST ANIMALS
- Source: Isf:(NZW), Isaac's Farm, Litchfield, Illinois)
- Age at study initiation:
- Weight at study initiation:2.51-2.79kg
- Fasting period before study: No data available
- Housing: Each animal was identified by ear tag and bar coded cage card.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): No data available
- Humidity (%):No data available
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To:
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- physiological saline
- Details on dermal exposure:
- DOSAGE PREPARATION (if unusual): The test material, ground with a mortar and pestle and moistened with physiological saline,
TEST SITE
- Area of exposure: Dorsal surface
- % coverage: no data
- Type of wrap if used: occlusive wrap of latex rubber
secured by bandaging and elastic tape
REMOVAL OF TEST SUBSTANCE
- Washing (if done): material was wiped from the animal.
- Time after start of exposure:24hr
TEST MATERIAL
- Amount(s) applied (volume or weight with unit):5000mg/kg bw
- Concentration (if solution): No data available
- Constant volume or concentration used: yes/no
- For solids, paste formed: yes,The test material, ground with a mortar and
pestle and moistened with physiological saline
VEHICLE
- Amount(s) applied (volume or weight with unit):No data available
- Concentration (if solution):No data available
- Lot/batch no. (if required): No data available
- Purity:No data available - Duration of exposure:
- 24hr(test material was held in place by means of an occlusive wrap of latex rubber secured by bandaging and elastic tape. The occlusive wrap was removed after approximately 24 hours and the excess material was wiped from the animal.)
- Doses:
- 5000mg/kg
- No. of animals per sex per dose:
- 5 male and 5 female
- Control animals:
- not specified
- Details on study design:
- Details on study design
- Duration of observation period following administration: 15 days
- Frequency of observations and weighing: Clinical observations were made three times during the first eight hours following test
material administration and twice daily (morning and afternoon) thereafter, with the exceptions of one day when observations were only recorded once and another day when
Observations were only recorded once for nine of the animals. Body weights were recorded on days a (day of exposure), 7, and 14.
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight, were done
other: - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: No mortality was observed
- Mortality:
- No mortality was observed
- Clinical signs:
- other: No clinical abnormalities were observed.
- Gross pathology:
- At necropsy, one male animal had pale colored kidneys, one female animal had kidneys with pale, mottled exteriors, and another female had tapeworm cysts in the mesentery.None of these effects were attributed to toxicity of the test material.
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- The LD 50 was considered to be >5000 mg/kg .When rabbits treated with Cyanuric acid (108-80-5) by dermal application.
- Executive summary:
An acute dermal toxicity study of Cyanuric acid(108-80-5) was carried out on New Zealand White rabbits. A group of 5 male and 5 female rabbits were given a single dose of 5000mg/kg bw test materialground with a mortar and pestle and moistened with physiological saline, on the dorsal Surface. Before application the skin on the dorsal surface of each animal was shaved with an electric clipper and abraded with a hypodermic needle.Test materialwas held in place by means of an occlusive wrap of latex rubber secured by bandaging and elastic tape. The occlusive wrap was removed after approximately 24 hoursand the excess material was wiped from the animal. Clinical observations were made three times during the first eight hours following test material administration and twice daily (morning and afternoon) thereafter, with the exceptions of one day when observations were only recorded once and another day when observations were only recorded once for nine of the animals. Body weights were recorded on days a (day of exposure), 7, and 14.No mortality was observed at dose 5000mg/kg bw.At necropsy, one male animal had pale colored kidneys, one female animal had kidneys with pale, mottled exteriors, and another female had tapeworm cysts in the mesentery. None of these effects were attributed to toxicity of the test material. Also no clinical abnormalities were observed.Therefore LD 50 was considered to be >5000 mg/kg .When rabbits treated with Cyanuric acid(108-80-5) by dermal application.
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