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EC number: 204-567-7 | CAS number: 122-70-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute Toxicity Studies with Insect Attractants
- Author:
- Morton Beroza, M. N. Inscoe, P. H. Schwartz, Jr., M. L. Keplinger, and C. W. Mastri
- Year:
- 1 975
- Bibliographic source:
- Toxicology and Applied Pharmacology 31,421-429
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- The primary skin irritation test for 2-phenylethyl propanoate (CAS No: 122-70-3) was conducted on six New Zealand albino rabbits to assess its adverse effects on skin.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenethyl propionate
- EC Number:
- 204-567-7
- EC Name:
- Phenethyl propionate
- Cas Number:
- 122-70-3
- Molecular formula:
- C11H14O2
- IUPAC Name:
- 2-phenylethyl propanoate
- Test material form:
- liquid
- Details on test material:
- - Name of test material : 2-phenylethyl propanoate
- Molecular formula: C11H14O2
- Molecular weight: 178.2296 g/mol
- Smiles notation: c1(CCOC(=O)CC)ccccc1
- InChl: 1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material (IUPAC name): 2-phenylethyl propanoate
- Common name: Phenethyl propionate (PEP)
- Molecular formula: C11H14O2
- Molecular weight: 178.2296 g/mol
- Smiles notation: c1(CCOC(=O)CC)ccccc1
- InChl: 1S/C11H14O2/c1-2-11(12)13-9-8-10-6-4-3-5-7-10/h3-7H,2,8-9H2,1H3
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- rabbit
- Strain:
- other: New Zealand albino
- Details on test animals or test system and environmental conditions:
- Weight at study initiation: 1.9-3.1 kg
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- clipped
- Remarks:
- intact and abraded
- Vehicle:
- not specified
- Controls:
- not specified
- Amount / concentration applied:
- concentration applied :70%
Amount :0.5 ml per dose - Duration of treatment / exposure:
- 24 hours
- Observation period:
- 24/72 hours
- Number of animals:
- 6 rabbits (Male and Female)
- Details on study design:
- TEST SITE
Area of exposure: back and flanks
% coverage: Not reported
Type of wrap if used: 2-in.-square gauze patches that were secured with masking tape, and the trunk of each animal was wrapped with plastic sheeting to maintain the patches in position
REMOVAL OF TEST SUBSTANCE
- Time after start of exposure: 24 and 72 hours
SCORING SYSTEM: Draize scoring system; maximum score is 8.0
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 24and 72 hours
- Score:
- 1.2
- Max. score:
- 8
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No skin irritation was observed in treated animals.
Applicant's summary and conclusion
- Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material 2-phenylethyl propanoate (CAS No: 122-70-3) was evaluated for primary skin irritation in six New Zealand albino rabbits. It was observed to have a Mean Primary Irritation Score of 1.2. Thus according to FIFRA categories for skin irritation, 2-phenylethyl propanoate (CAS No: 122-70-3) was considered to be not irritating (Primary Irritation Score <5).
- Executive summary:
The primary skin irritation test for chemical 2-phenylethyl propanoate (CAS No: 122-70-3) was conducted on six New Zealand albino rabbits to assess its adverse effects on skin.
During the test,the hairs were clipped from the back and flanks of rabbits, and two sites located lateral to the midline of the back and approximately 10 cm apart were selected for the test; one site was abraded by making four epidermal incisions, two perpendicular to the other were selected for the test; one site was abraded by making four epidermal incisions, were selected for the test; one site was abraded by making four epidermal incisions, two perpendicular to the other two.
A 0.5-ml dose of 70%2-phenylethyl propanoatewas applied to each site. The sites were immediately covered with 2-in.-square gauze patches that were secured with masking tape, and the trunk of each animal was wrapped with plastic sheeting to maintain the patches in position and retard evaporation of the test material.
After 24 hr the plastic wrappings and gauze patches were removed, and the intact and abraded skin sites were scored separately for erythema and edema on a graded scale of 0 to 4 according to Draize scoring system after 72 hr, the sites were scored again. The mean primary irritation score (maximum = 8) represents an average of the 24- and 72-hr ratings of the intact and abraded sites.
For skin irritation, the category for to be not an irritant was, if no irritation was observed or the primary irritation score was <5according to FIFRA.
The 2-phenylethyl propanoatewas observed to have a Mean Primary Irritation Score of 1.2. Thusaccording to FIFRA categories for skin irritation,2-phenylethyl propanoate (CAS No: 122-70-3) was considered to be not irritating (Primary Irritation Score <5).
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