Registration Dossier
Registration Dossier
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EC number: 416-020-1 | CAS number: 96314-26-0
Guidance on Safe Use
Guidance on Safe Use
Administrative data
First-aid measures
Eye contact Rinse immediately with plenty of water for at least 15 minutes. Keep eye wide open while
rinsing. Obtain medical attention.
Skin contact If ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs, seek
medical advice/attention. Wash contaminated clothing before re-use.
Inhalation Move to fresh air. Oxygen or artificial respiration if needed. If exposed or concerned: Get
medical attention/advice.
Ingestion Do NOT induce vomiting. If exposed or concerned: Get medical attention/advice.
Medical Surveillance A pre-placement physical examination and history for employees with potential exposure to
this compound is recommended. Baseline testing would include: a blood test for kidney
function, a complete blood count with differential. Based on opportunity for exposure and
duration of exposure a periodic follow-up examination may be considered. This exam
should be overseen by a physician thoroughly knowledgeable about both the toxicity of this
compound and the extent of work place exposure. It is recommended that the content be
similar to the pre-placement exam.
Employees who are pregnant, are breast-feeding, or who are concerned with other
reproductive issues should be encouraged to consult with the occupational health physician
monitoring worker's health.
rinsing. Obtain medical attention.
Skin contact If ON SKIN: Wash with plenty of soap and water. If skin irritation or rash occurs, seek
medical advice/attention. Wash contaminated clothing before re-use.
Inhalation Move to fresh air. Oxygen or artificial respiration if needed. If exposed or concerned: Get
medical attention/advice.
Ingestion Do NOT induce vomiting. If exposed or concerned: Get medical attention/advice.
Medical Surveillance A pre-placement physical examination and history for employees with potential exposure to
this compound is recommended. Baseline testing would include: a blood test for kidney
function, a complete blood count with differential. Based on opportunity for exposure and
duration of exposure a periodic follow-up examination may be considered. This exam
should be overseen by a physician thoroughly knowledgeable about both the toxicity of this
compound and the extent of work place exposure. It is recommended that the content be
similar to the pre-placement exam.
Employees who are pregnant, are breast-feeding, or who are concerned with other
reproductive issues should be encouraged to consult with the occupational health physician
monitoring worker's health.
Fire-fighting measures
Flammable Properties Not a readily combustible solid
Extinguishing Media Suitable extinguishing media: Dry chemical, Water spray, Foam
Unsuitable extinguishing media: Do NOT use water jet.
Protection of
Firefighters
Specific hazards: Skin sensitizer Reproductive toxicant
Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained
breathing apparatus.
Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx)
Other information Avoid generating dust; fine dust dispersed in air in sufficient concentrations, and in the
presence of an ignition source is a potential dust explosion hazard. Decontaminate
protective clothing and equipment before reuse.
Extinguishing Media Suitable extinguishing media: Dry chemical, Water spray, Foam
Unsuitable extinguishing media: Do NOT use water jet.
Protection of
Firefighters
Specific hazards: Skin sensitizer Reproductive toxicant
Protective equipment: Use personal protective equipment. In the event of fire, wear selfcontained
breathing apparatus.
Hazardous Combustion Products: carbon oxides (COx), nitrogen oxides (NOx)
Other information Avoid generating dust; fine dust dispersed in air in sufficient concentrations, and in the
presence of an ignition source is a potential dust explosion hazard. Decontaminate
protective clothing and equipment before reuse.
Accidental release measures
Personal precautions Refer to protective measures listed in sections 7 and 8. Use personal protective equipment.
Examples include tightly fitting safety goggles, disposable lab coat of low permeability
with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the
nature of the spill (quantity and extent of spill) additional protective clothing and
equipment such as a self-contained breathing apparatus may be needed.
Environmental
precautions
Prevent release to drains and waterways. Prevent release to the environment.
Containment Methods Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable
material.
Cleanup Methods Spill prevention procedures and a spill response procedure should be implemented.
Contain and collect spillage and place in container for disposal according to local
regulations (see Section 13). Clean spill area with a deactivating solution (if available)
followed by detergent and water after spill pick-up. Handle waste materials, including
gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for
chemically and pharmacologically similar materials.
Other information Dust deposits should not be allowed to accumulate on surfaces, as these may form an
explosive mixture if they are released into the atmosphere in sufficient concentration.
Avoid dispersal of dust in the air (i.e., clearing dust surfaces with compressed air).
Nonsparking tools should be used.
Examples include tightly fitting safety goggles, disposable lab coat of low permeability
with cuffs, double gloves and shoe covers. Wear respiratory protection. Depending on the
nature of the spill (quantity and extent of spill) additional protective clothing and
equipment such as a self-contained breathing apparatus may be needed.
Environmental
precautions
Prevent release to drains and waterways. Prevent release to the environment.
Containment Methods Wet down any dust to prevent generation of aerosols, if appropriate. Cover with suitable
material.
Cleanup Methods Spill prevention procedures and a spill response procedure should be implemented.
Contain and collect spillage and place in container for disposal according to local
regulations (see Section 13). Clean spill area with a deactivating solution (if available)
followed by detergent and water after spill pick-up. Handle waste materials, including
gloves, protective clothing, contaminated spill cleanup material, etc., as appropriate for
chemically and pharmacologically similar materials.
Other information Dust deposits should not be allowed to accumulate on surfaces, as these may form an
explosive mixture if they are released into the atmosphere in sufficient concentration.
Avoid dispersal of dust in the air (i.e., clearing dust surfaces with compressed air).
Nonsparking tools should be used.
Handling and storage
Handling Precautions Highly potent material. Avoid exposure - obtain special instructions before use. Avoid
formation of dust and aerosols. Keep away from heat and sources of ignition. Use of inert
gas should be considered for process conditions to minimize the risk of ignition. Minimize
dust generation and accumulation. Routine housekeeping should be instituted to ensure
that dusts do not accumulate on surfaces. Dry powders can build static electricity charges
when subjected to the friction of transfer and mixing operations. Provide adequate
precautions, such as electrical grounding and bonding, or inert atmospheres. Prevent release to drains and waterways.
Container
Requirements
Store in sturdy containers appropriate to maintain the integrity of this material for its
intended use. Provide anti-static bags where drum liners are used.
Storage Conditions Store at room temperature in the original container. 15 - 30°C Keep away from heat,
sparks and flames. Protect against light. Avoid moisture.
formation of dust and aerosols. Keep away from heat and sources of ignition. Use of inert
gas should be considered for process conditions to minimize the risk of ignition. Minimize
dust generation and accumulation. Routine housekeeping should be instituted to ensure
that dusts do not accumulate on surfaces. Dry powders can build static electricity charges
when subjected to the friction of transfer and mixing operations. Provide adequate
precautions, such as electrical grounding and bonding, or inert atmospheres. Prevent release to drains and waterways.
Container
Requirements
Store in sturdy containers appropriate to maintain the integrity of this material for its
intended use. Provide anti-static bags where drum liners are used.
Storage Conditions Store at room temperature in the original container. 15 - 30°C Keep away from heat,
sparks and flames. Protect against light. Avoid moisture.
Transport information
Shippingopen allclose all
SpecialProvisionsopen allclose all
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Remarksopen allclose all
Marine transport (UN RTDG/IMDG)
Shippingopen allclose all
Remarksopen allclose all
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Remarksopen allclose all
SpecialProvisionsopen allclose all
Exposure controls / personal protection
Engineering
Controls and
Ventilation
Use process enclosures, containment technology, or other engineering controls to keep
airborne levels below recommended exposure limit. When handling quantities up to 3
milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air
changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a
standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood,
biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved
vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly
"dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated
laboratory or containment facility using appropriate containment technology. A laminar
flow/powder containment booth or appropriate isolation technology should be considered for
handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For
manufacturing and pilot plant operations, barrier/containment technology and direct coupling
(totally enclosed processes that create a barrier between the equipment and the room) with use
of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation
solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box
systems are optional. HEPA filtration of exhaust from dry product handling areas is required.
It is recommended that all dust control equipment such as local exhaust ventilation and
material transport systems involved in handling of this product contain explosion relief vents
or an explosion suppression system or an oxygen deficient environment. Ensure that dusthandling
systems (such as exhaust ducts, dust collectors, vessels, and processing equipment)
are designed in an manner to prevent the escape of dust into the work area (i.e., there is no
leakage from the equipment). Use only appropriately classified electrical equipment and
powered industrial trucks.
Respiratory
protection
Use and selection of respiratory protection is based upon engineering controls in use and
potential for aerosol generation. When engineering controls are not sufficient control
exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate
(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure
control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying
respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control
guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters
(EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting,
full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure
control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied
air respirator (EN 139) operated in a pressure demand or other positive pressure mode when
exposures are 100-1000 times the exposure control guideline.
Eye protection Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety
goggles (EN 166) may be required if splash potential exists or if corrosive materials are
present. Note: Choice of eye protection may be influenced by the type of respirator which is
selected.
Hand protection Wear gloves at all times when handling containers, including when unpacking, inspecting or
transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374).
Double gloving for all manufacturing personnel potentially in direct contact with the
compound should be considered. If material is handled in solution, the solvent should also be
considered when selecting protective clothing material.
Skin and body
protection
Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up
to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN
1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable
coverall of low permeability (EN 1149-1) and disposable shoe covers.
Hygiene Wash hands and face before breaks and immediately after handling the product.
Environmental
exposure controls
Prevent release to drains and waterways.
Controls and
Ventilation
Use process enclosures, containment technology, or other engineering controls to keep
airborne levels below recommended exposure limit. When handling quantities up to 3
milligrams, a standard laboratory with general laboratory dilution ventilation (e.g. 6-12 air
changes per hour) is appropriate. When handling quantities up to 1 kilogram, work in either a
standard laboratory (<500 g) or designated laboratory (500 g to <1 kg) using a fume hood,
biological safety cabinet(Class II, Type A2 with thimble connection, B1, or B2)or approved
vented enclosure. HEPA filtered exhaust preferred for fume hoods containing particularly
"dusty" operations. Quantities exceeding 1 kilogram should be handled in a designated
laboratory or containment facility using appropriate containment technology. A laminar
flow/powder containment booth or appropriate isolation technology should be considered for
handling more than 1 kilogram of active compound. HEPA filtered exhaust preferred. For
manufacturing and pilot plant operations, barrier/containment technology and direct coupling
(totally enclosed processes that create a barrier between the equipment and the room) with use
of double or split butterfly valves, hybrid unidirectional airflow/local exhaust ventilation
solutions (e.g. powder containment booth) should be used. Glove bags, isolator/glove box
systems are optional. HEPA filtration of exhaust from dry product handling areas is required.
It is recommended that all dust control equipment such as local exhaust ventilation and
material transport systems involved in handling of this product contain explosion relief vents
or an explosion suppression system or an oxygen deficient environment. Ensure that dusthandling
systems (such as exhaust ducts, dust collectors, vessels, and processing equipment)
are designed in an manner to prevent the escape of dust into the work area (i.e., there is no
leakage from the equipment). Use only appropriately classified electrical equipment and
powered industrial trucks.
Respiratory
protection
Use and selection of respiratory protection is based upon engineering controls in use and
potential for aerosol generation. When engineering controls are not sufficient control
exposure, wear an approved respirator with NIOSH Class 100 or high efficiency particulate
(HEPA) filters or cartridges (EN 140/EN 136) when exposures are up to 10 times the exposure
control guideline. Wear a loose-fitting (Tyvek or helmet type) HEPA powered-air purifying
respirator (PAPR) (EN 12941) when exposures are 10-25 times the exposure control
guideline. Wear a full facepiece negative pressure respirator with Class 100 or HEPA filters
(EN 136) when exposures are 25-50 times the exposure control guideline. Wear a tightfitting,
full facepiece HEPA PAPR (EN 12942) when exposures are 50-100 times the exposure
control guideline. Wear a hood-shroud HEPA PAPR (EN 12941) or full facepiece supplied
air respirator (EN 139) operated in a pressure demand or other positive pressure mode when
exposures are 100-1000 times the exposure control guideline.
Eye protection Safety glasses with side-shields are recommended (EN 166). Face shields or chemical safety
goggles (EN 166) may be required if splash potential exists or if corrosive materials are
present. Note: Choice of eye protection may be influenced by the type of respirator which is
selected.
Hand protection Wear gloves at all times when handling containers, including when unpacking, inspecting or
transporting within a facility. Impervious gloves are recommended. (EN 420, EN 374).
Double gloving for all manufacturing personnel potentially in direct contact with the
compound should be considered. If material is handled in solution, the solvent should also be
considered when selecting protective clothing material.
Skin and body
protection
Wear a laboratory coat (EN 340) when handling quantities up to 500 grams. For quantities up
to 1 kilogram, wear disposable laboratory coat (EN 340) or coverall of low permeability (EN
1149-1) . For quantities over 1 kilogram and manufacturing operations, wear disposable
coverall of low permeability (EN 1149-1) and disposable shoe covers.
Hygiene Wash hands and face before breaks and immediately after handling the product.
Environmental
exposure controls
Prevent release to drains and waterways.
Stability and reactivity
Chemical
Stability
Stable under normal conditions.
Conditions to
avoid
Not available
Materials to
avoid
Not available
Hazardous
decomposition
products
Hazardous decomposition products formed under fire conditions.: carbon oxides (COx),
nitrogen oxides (NOx)
Hazardous
reactions
None known
Stability
Stable under normal conditions.
Conditions to
avoid
Not available
Materials to
avoid
Not available
Hazardous
decomposition
products
Hazardous decomposition products formed under fire conditions.: carbon oxides (COx),
nitrogen oxides (NOx)
Hazardous
reactions
None known
Disposal considerations
Advice On Disposal And Packaging Disposal should be in accordance with applicable regional, national and local
laws and regulations. Local regulations may be more stringent than regional
or national requirements. This information presented only applies to the
material as supplied.
Other information Disposal by incineration is recommended.
laws and regulations. Local regulations may be more stringent than regional
or national requirements. This information presented only applies to the
material as supplied.
Other information Disposal by incineration is recommended.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
