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Diss Factsheets
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EC number: 235-845-6 | CAS number: 13005-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, however not sufficient for C & L as only two parameters were obsersed at 72 hr.
Data source
Reference
- Reference Type:
- publication
- Title:
- Comparative studies on the irritancy of oils and synthetic perfumes to the skin of rabbits, guinea pigs, rat, miniature swine and man.
- Author:
- Mototoshi K, Toyoshima Y, Sato M, Yoshimura M
- Year:
- 1 979
- Bibliographic source:
- Cosmetics and Toiletries.94(8).41-43
Materials and methods
- Principles of method if other than guideline:
- From a large number of cosmetic raw materials, 39 test compounds (19 oils and 20 synthetic perfumes (which include Phenylethyl alcohol) were chosen to perform irritancy potential in Japan.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Phenyl ethyl alcohol
- IUPAC Name:
- Phenyl ethyl alcohol
- Details on test material:
- - Analytical purity:> 98%
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Angora
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Housing:Animals were maintained in individual stainless steel cages
- Weight at study initiation:2.3 to 3.0 kg (average weight 2.6 kg)
- Diet (e.g. ad libitum):Food were permitted
- Water (e.g. ad libitum):Water were permitted
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- other: Yes. Hexadecane was reagent grade and used as a control
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied :0.1 g of 100% test compound - Duration of treatment / exposure:
- 24 hours then second exposure for 30 min.
- Observation period:
- 24 hr and at 72 hr
- Number of animals:
- 6 animals in the treatment group and the control
- Details on study design:
- TEST SITE
- Area of exposure:The hair on a area of the dorsal surface of each animal was clipped as close to the skin as possible using an electric clipper.The test areas measured 3 x 3 cm and were approximately 2 cm apart
- Type of wrap if used:A 25 cm diameter plastic collar was wrapped around the neck of each rabbit
SCORING SYSTEM: See table 1 for details
Results and discussion
In vivo
Results
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- mean
- Time point:
- other: 72 h
- Score:
- 2
- Reversibility:
- no data
- Remarks on result:
- other: measurements only made at 72 hours
Any other information on results incl. tables
The dilating rate of blood vessels, the swelling rate (edema), the bluing rate (as a result of increased capillary permeability), and the bleeding rate on the test sites were read using transmitting light. The total score of the averages of the reddening rate ( erythema, 72 hr reading), the dilating rate, the swelling rate, and the bluing rate for 6 animals in a group was referred to as the primary irritation index.
Table 2. Relative irritancy of 100 and 32 % concentrations of test compounds (synthetic perfumes) in the skin of rabbit
Compound |
Rabbit (100%) |
Phenyl ethyl alcohol |
2 |
Scoring : 0 = negative, 1= mildly irritating, 2= moderately irritating, 3= severely irritating
Applicant's summary and conclusion
- Interpretation of results:
- moderately irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: other: See any other information on f materials and methods iclu.tables
- Conclusions:
- Phenyl ethyl alcohol was concluded as moderately irritant.
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