Registration Dossier
Registration Dossier
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EC number: 207-668-4 | CAS number: 488-10-8
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- April 1977
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: One page summary, no guideline included and study not GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- No guideline followed
- GLP compliance:
- no
Test material
- Reference substance name:
- 3-methyl-2-pent-2-enylcyclopent-2-enone
- EC Number:
- 207-668-4
- EC Name:
- 3-methyl-2-pent-2-enylcyclopent-2-enone
- Cas Number:
- 488-10-8
- Molecular formula:
- C11H16O
- IUPAC Name:
- 3-methyl-2-pent-2-enylcyclopent-2-enone
- Reference substance name:
- (E)-3-methyl-2-(pent-2-enyl)cyclopent-2-en-1-one
- EC Number:
- 228-410-7
- EC Name:
- (E)-3-methyl-2-(pent-2-enyl)cyclopent-2-en-1-one
- Cas Number:
- 6261-18-3
- Molecular formula:
- C11H16O
- IUPAC Name:
- 3-methyl-2-pent-2-en-1-ylcyclopent-2-en-1-one
- Test material form:
- liquid
Constituent 1
impurity 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- not specified
- Controls:
- not specified
- Duration of treatment / exposure:
- No data
- Observation period:
- 14 days
- Number of animals:
- 10
Results and discussion
In vivo
Resultsopen allclose all
- Remarks on result:
- other: substance is an irritant
- Irritation parameter:
- edema score
- Basis:
- other: all
- Time point:
- 14 d
- Reversibility:
- not specified
- Remarks on result:
- other: moderate in 10
- Irritation parameter:
- other: redness
- Basis:
- other: all
- Time point:
- 14 d
- Reversibility:
- not specified
- Remarks on result:
- other: moderate in 1, severe in 9
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Reversibility:
- not specified
- Remarks on result:
- not measured/tested
Any other information on results incl. tables
5 g/kg irritant effects.
Moderate redness in 1, severe redness in 9 and moderate edema in all 10.
Bleeding at exposure site in 1, slight eschar in 2, heavy eschar in 1 and severe escar in 1.
Applicant's summary and conclusion
- Interpretation of results:
- irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Jasmone-Cis is irritating.
- Executive summary:
Jasmone-Cis is irritating.
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