Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: only secondary literature
Data source
Referenceopen allclose all
- Reference Type:
- other: ECHA disseminated dossier
- Title:
- ECHA disseminated dossier
- Year:
- 2 014
- Bibliographic source:
- ECHA disseminated dossier
- Report date:
- 2014
- Reference Type:
- secondary source
- Title:
- not applicable
- Author:
- not applicable
- Year:
- 2 008
- Bibliographic source:
- GESTIS-database on hazardous substances - Information system on hazardous substances of the German Social Accident Insurance
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Rats and guinea pigs were exposed to vapors and aerosols of trifluoroacetic acid for 4 hrs/day during 5 or 4 months.
- GLP compliance:
- not specified
- Limit test:
- no
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
Constituent 1
Test animals
- Species:
- other: rats and guinea pigs
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- other: inhalation of vapours and aerosols
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Remarks on MMAD:
- MMAD / GSD: no data
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 4 hrs/day for 5 months (rats) or 4 months (guinea pigs)
- Frequency of treatment:
- 6 times a week
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.4-0.7 mg/L (guinea pigs)
Basis: no data
- Remarks:
- Doses / Concentrations:
0.025-0.05 mg/L (rats)
Basis: no data
- No. of animals per sex per dose:
- 48 rats (12 served as control) or 30 guinea pigs (10 served as control).
- Control animals:
- yes
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- LOAEL
- Effect level:
- < 0.05 mg/L air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: LOAEL (rat): severe signs of irritation on the respiratory pathway and the eyes, effects in the liver and kidney, and body weight loss.
- Dose descriptor:
- LOAEL
- Effect level:
- < 0.7 mg/L air
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: LOAEL (guinea pig): severe signs of irritation on the respiratory pathway and the eyes, effects in the liver and kidney, and body weight loss.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
