Registration Dossier
Registration Dossier
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EC number: 200-929-3 | CAS number: 76-05-1
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Some essential data are missing but in general a scientifically sound paper.
Data source
Reference
- Reference Type:
- publication
- Title:
- Toxic Actions of the Metabolites of Halothane: LD50 and Some Metabolic Effects of Trifluoroethanol and Trifluoroacetic Acid in Mice and Guinea Pigs
- Author:
- Airaksinen MM and Tammisto T
- Year:
- 1 968
- Bibliographic source:
- Ann. Med. Exp 46: 242 - 248
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Limit test:
- no
Test material
- Reference substance name:
- Trifluoroacetic acid
- EC Number:
- 200-929-3
- EC Name:
- Trifluoroacetic acid
- Cas Number:
- 76-05-1
- Molecular formula:
- C2HF3O2
- IUPAC Name:
- trifluoroacetic acid
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- not specified
- Sex:
- male
Administration / exposure
- Route of administration:
- other: intraperitoneal and intravenously
- Vehicle:
- water
- Doses:
- 4 - 6 doses, not detailed.
- No. of animals per sex per dose:
- 5 - 40 mice per dose
- Control animals:
- other: yes, but used as a basis for comparison for other measurements/ parameters than mortality e.g ATP, lactic acid, pyravic acid and citric acid content in mice tissues.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: administered intraperitoneally
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 1 200 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: administered intravenously
Any other information on results incl. tables
The test substance had no effect on all other parameters tested in the study (levels of ATP, lactic acid, pyruvic acid in liver and muscle and citric acid in brain, muscle, heart and kidney).
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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