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EC number: 813-266-5 | CAS number: 45101-66-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Description of key information
Low concern regarding genotoxicity of 6-chlorohexyl methacrylate (6-CHMA) should be assumed based on in vitro and in vivo studies for similar substances belong to the category "short chain alkyl methacrylates".
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Genetic toxicity in vivo
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
No data is available for genetic toxicity of 6-chlorohexyl methacrylate (6-CHMA). No concern regarding genetic toxicity of 6-CHMA is expected based on the similarity with short chain alkyl methacrylates and in particular with 2-ethylhexyl methacrylate CAS 688-84-6 (see document "Read -across hypothesis and justification" in section 13 of this IUCLID dossier).
In vitro studies
No in vitro genetic study is available for 6-chlorohexyl methacrylate (6-CHMA). No concern regarding in vitro genetic toxicity of 6-CHMA is expected based on the experimental data reported in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) for these similar compounds: the methacrylate esters have been tested in vitro and in vivo for gene mutations, chromosome mutations and aneugenic effects over relevant dose ranges and there is no indication that the methacrylate esters in the category cause gene mutations.
In particular, in SIDS Dossier of " Short chain alkyl methacrylates" approved at SIAM 18 (20-23 April 2004) inside the specific section of 2-ethylhexyl methacrylate CAS 688-84-6 (2 -EHMA) two in vitro genetic studies are reported:
1)Bacterial test: Negative result in a study conducted in 1998 according to OECD471 and OECD 472 on S. typh.(strains TA100, TA1535, TA98, TA1537) and E. coli WP2 uvr A at concentration of 0.6-5000μg/plate (Ref. Miyagawa et all, 1998, Reverse Mutation Test of Ethylhexyl Methacrylate on Bacteria. Study on behalf of Ministry of Health and Welfare, Japan).
2) Chromosome aberration test on chinese hamster lung: Negative result in a study conducted in 1998 according to OECD473 at concentration of 10-80 μg/ml(without S9) and 625-5000μg/ml (with S9)(Ref.Ohta et all, 1998,In Vitro Chromosome aberration Test of 2-Ethyl Hexyl Methacrylate on Cultured Chinese Hamster Cells, Mitsubishi Chemicals Safety Institute Ltd., unpublished report, study on behalf of Ministry of Health and Welfare, Japan).
In vivo studies
No in vivo study is available for 6-chlorohexyl methacrylate (6-CHMA) neither for most similar short chain alkyl methacrylates, 2-ethylhexyl methacrylate (2-EHMA) CAS 688-84-6. Some in vivo genetic studies are available for other short chain alkyl methacrylates with negative results.
In conclusion, low concern regarding genotoxicity of for 6-chlorohexyl methacrylate (6-CHMA) should be assumed based on in vitro and in vivo studies for similar substances.
Justification for classification or non-classification
Low concern regarding genotoxicity of 6-chlorohexyl methacrylate (6-CHMA) should be assumed based on its similarity with short chain alkyl methacrylates.
No classification for genetic toxicity of 6-chlorohexyl methacrylate (6-CHMA)is proposed according to the CLP Regulation (EC n.1272/2008).
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