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Diss Factsheets
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EC number: 701-052-3 | CAS number: 146987-98-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well conducted study with limitation (documentation in german, without GLP)
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 985
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Orientation study to determine the acute oral toxicity. Two dosages used, compareable to OECD fixed dosed procedure (420).
- GLP compliance:
- not specified
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Dehyton K-precursor
- IUPAC Name:
- Dehyton K-precursor
- Details on test material:
- Conversion product of coconut fatty acid with N,N disubstituted propylendiamine.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor:WISW, Fa. Winkelmann, Borchen.
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source:Fa. Winkelmann, Borchen
- Weight at study initiation: 172/175 or 151/165 g
- Fasting period before study: yes
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- application of the pure or water diluted test item was performed via gavage after fastening
- Doses:
- 2000mg/kg bw, 200mg/kg bw (diluted with dest. water)
- No. of animals per sex per dose:
- 2-5 male
2-5 female - Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Other examinations performed: clinical signs, gross pathology - Statistics:
- no statistical tests are conducted
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 200 - < 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: only two dosages tested
- Mortality:
- 2000mg/kg bw:
20% dead males
80% dead females
200mg/kg bw:
0% dead males
0% dead females - Clinical signs:
- other: 2000mg/kg bw: piloerection, reduced activity, heavy breathing, easily scared behaviour, wobbling motion, Diarrhoea, red-braun fur in head area, semi closed eyes 200mg/kg bw: no unusual signs
- Gross pathology:
- 2000 mg/kg bw:
Fluffy stomach content, baggy appendix, unformed rectum content, red area in the left proventriculus (typical area for application caused irritation), pulmonary emphysema
200mg/kg bw:
no unusual signs
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: other: EU GHS (REGULATION (EC) No 1272/2008)
- Conclusions:
- Based on the available finding (LD50(f) >200 < 2000 mg/kg bw) the substance has to be classified as
- Executive summary:
The conversion product of coconut fatty acid with N,N disubstituted propylendiamine was test in a orientation study to determine the acute oral toxicity. Therefore to dosages (2000mg/kg bw and 200mg/kg bw) of the test substance were applied via gavage to 2-5 female and male strain Bor:WISW, Fa. Winkelmann, Borchen. Clinical signs were observed for a period of 14days and gross pathology was conducted.
The 2000mg/kg group shows 20% dead males and 80% dead females. Clinical signs are piloerection, reduced activity, heavy breathing, easily scared behaviour, wobbling motion,
Diarrhoea, red-braun fur in head area, semi closed eyes, whereas the 200mg/kg bw group reveals no death or any other usual signs.
Therefore the LD50 was determined to be >2000 mg/kg bw for males and >200 mg/kg bw <2000 mg/kg bw for females.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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