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EC number: 237-748-4 | CAS number: 13967-50-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- November 5th - Novermber 21st 1991
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP compliant, follows standard guidelines. Available as an unpublished report, acceptable without restrictions.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 (Acute Toxicity (Oral))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Potassium dicyanoaurate
- EC Number:
- 237-748-4
- EC Name:
- Potassium dicyanoaurate
- Cas Number:
- 13967-50-5
- Molecular formula:
- C2AuN2.K
- IUPAC Name:
- potassium dicyanoaurate
- Details on test material:
- - Name of test material (as cited in study report): Potassium dicyanoaurate(I)
- Physical state: White crystalline powder
- Storage condition of test material: dry, cool
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Bor: WISW (SPFCpb)
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Winkelmann Versuchtierzucht GmbH & Co. KG., D-4799 Borchen
- Age at study initiation: Males: 8 weeks; Females: 9 weeks
- Weight at study initiation: Males: 138 - 168 g; Females: 137 - 148 g
- Fasting period before study: Approx. 16 hours
- Housing: 1 animal per cage. Macrolon cages (type II).
- Diet (e.g. ad libitum): ssniff R, Special diet for rats. ad libitum.
- Water (e.g. ad libitum): ad libitum
- Acclimation period: ≥5 days under test conditions.
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20.5 - 23°C
- Humidity (%): 40 - 60%
- Photoperiod (hrs dark / hrs light): 6 a.m.- 6 p.m. CET artififical lighting, 6 p.m. - 6 a.m. CET natural light-dark-rhythm.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Remarks:
- desalted water
- Details on oral exposure:
- VEHICLE
Test item in aqueous solution.
MAXIMUM DOSE VOLUME APPLIED: 2.5 ml/kg b.w. - Doses:
- 10.0, 21.5, 46.4 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation for mortalities: 0.5, 1, 2, 4, 6, 24 hours, daily thereafter; Weighing: days 0, 7 and 14
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs - Statistics:
- LD50 values calculated by Probit analysis
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 36.1 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 14.6 - 66.9
- Remarks on result:
- other: Slope of dose response curve: 7.76
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 24.4 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 12.6 - 50.8
- Remarks on result:
- other: Slope of dose response curve: 4.56
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 29.2 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 21.7 - 39.8
- Remarks on result:
- other: Slope of dose response curve: 6.45
- Mortality:
- At the 21.5 mg/kg treatment level 2 females were found dead at 24 hours.
At the 46.4 mg/kg treatment level 1 male was found dead at 4 hours. 3 further males and 5 females were found dead at 24 hours. - Clinical signs:
- other: No clinical signs were observed in the 10.0 mg/kg b.w. treatment group. At higher doses rats of both sexes showed slight to moderate hypokinesia, restrained gait, piloerection, clonic convulsions and sunken sides. One male in the 46.4 mg/kg group addition
- Gross pathology:
- No macroscopic changes were observed in animals surviving at 14 days.
Of those that had died earlier male animals showed reddened small intestine and glandular stomach whilst females showed severely bloated stomach and hemorrages were found in the glandular stomach. Male and females exhibited stomachs that were tightly filled with liquid.
Any other information on results incl. tables
Table 1 - Body weights of the individual animals.
Dose (mg/kg) | Animal No. | Day 0 | Day 7 | Day 14 |
Males | ||||
10 | 1 | 153 | 197 | 222 |
2 | 156 | 201 | 239 | |
3 | 155 | 204 | 235 | |
4 | 160 | 204 | 233 | |
5 | 157 | 206 | 237 | |
21.5 | 11 | 167 | 200 | 246 |
12 | 156 | 192 | 233 | |
13 | 158 | 183 | 213 | |
14 | 159 | 195 | 234 | |
15 | 168 | 215 | 260 | |
46.4 | 21 | 160 | 189 | 221 |
22 | 164 | |||
23 | 164 | |||
24 | 158 | |||
25 | 138 | |||
Females | ||||
10 | 6 | 137 | 153 | 158 |
7 | 148 | 178 | 193 | |
8 | 145 | 155 | 158 | |
9 | 141 | 166 | 173 | |
10 | 142 | 165 | 170 | |
21.5 | 16 | 141 | 152 | 166 |
17 | 144 | 156 | 165 | |
18 | 145 | |||
19 | 140 | |||
20 | 143 | 159 | 167 | |
46.4 | 26 | 145 | ||
27 | 148 | |||
28 | 146 | |||
29 | 145 | |||
30 | 140 |
Applicant's summary and conclusion
- Interpretation of results:
- Category 2 based on GHS criteria
- Conclusions:
- In a 14 day acute toxicity test on male and female rats the LD50 of potassium dicyanoaurate was found to be 29.2 mg/kg.
- Executive summary:
In a 14 day acute toxicity test on male and female rats the LD50 of potassium dicyanoaurate was found to be 29.2 mg/kg. The female rats in the study were found to be more sensitive than the males.
The study was conducted to GLP standards and in accordance with standard guidelines.
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