Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-311-9 | CAS number: 94-18-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Long-term toxicity to fish
Administrative data
Link to relevant study record(s)
- Endpoint:
- fish, juvenile growth test
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed journal
- Qualifier:
- according to guideline
- Guideline:
- other: as per mentioned below
- Principles of method if other than guideline:
- Chronic toxicity test was performed on pimephales promelas by benzylparaben for 7 days.
- GLP compliance:
- no
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data available - Analytical monitoring:
- not specified
- Details on sampling:
- No data available
- Vehicle:
- not specified
- Details on test solutions:
- No data available
- Test organisms (species):
- Pimephales promelas
- Details on test organisms:
- Details on test organisms
TEST ORGANISM
- Common name: Fathead minnow
- Strain: No data available
- Source: No data available
- Age at study initiation (mean and range, SD): 24 h post hatch larvae
- Length at study initiation (length definition, mean, range and SD): No data available
- Weight at study initiation (mean and range, SD): No data available
- Method of breeding: No data available
- Feeding during test: Yes
- Food type: newly hatched Artemia nauplii
- Amount: No data available
- Frequency: twice daily
ACCLIMATION
- Acclimation period: No data available
- Acclimation conditions (same as test or not): No data available
- Type and amount of food: No data available
- Feeding frequency: No data available
- Health during acclimation (any mortality observed): No data available
QUARANTINE (wild caught)
- Duration: No data available
- Health/mortality: No data available - Test type:
- static
- Water media type:
- freshwater
- Total exposure duration:
- 7 d
- Post exposure observation period:
- No data available
- Hardness:
- 160 to 175 mg/L as CaCO3
- Test temperature:
- 24°C
- pH:
- 8.2 to 8.8
- Dissolved oxygen:
- No data available
- Salinity:
- No data available
- Nominal and measured concentrations:
- Five concentrations mention but not specified.
- Details on test conditions:
- Details on test conditions
TEST SYSTEM
- Test vessel: No data available
- Type (delete if not applicable): No data available
- Material, size, headspace, fill volume: 250 ml
- Aeration: Yes
- Type of flow-through (e.g. peristaltic or proportional diluter): No data available
- Renewal rate of test solution (frequency/flow rate): mention but not specified
- No. of organisms per vessel: 10
- No. of vessels per concentration (replicates): four replicates
- No. of vessels per control (replicates): No data available
- No. of vessels per vehicle control (replicates): No data available
- Biomass loading rate: No data available
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: test solution + a RHW and 0.1% acetone solvent control
- Total organic carbon: No data available
- Particulate matter: No data available
- Metals: No data available
- Pesticides: No data available
- Chlorine: No data available
- Alkalinity: 110 to 120 mg/L as CaCO3
- Ca/mg ratio: No data available
- Conductivity: 535 to 588 µS/cm
- Culture medium different from test medium: No data available
- Intervals of water quality measurement: No data available
OTHER TEST CONDITIONS
- Adjustment of pH: 8.2 to 8.8
- Photoperiod: 16:8 light: dark cycle
- Light intensity: No data available
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) : No data available
TEST CONCENTRATIONS
- Spacing factor for test concentrations: No data available
- Justification for using less concentrations than requested by guideline: No data available
- Range finding study: Half of the LC50 determined from the acute test was used as the highest sub chronic exposure concentration.
- Test concentrations: five concentration was mention but values are not specified (range from 1.0 to 25 mg/L)
- Results used to determine the conditions for the definitive study: No data available - Reference substance (positive control):
- not specified
- Duration:
- 7 d
- Dose descriptor:
- LOEC
- Effect conc.:
- 1.7 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- growth rate
- Details on results:
- No data available
- Results with reference substance (positive control):
- No data available
- Reported statistics and error estimates:
- No data available
- Validity criteria fulfilled:
- not specified
- Conclusions:
- The endpoint for benzylparaben (94-18-8) long term toxicity to P. promelas was found to be LOEC at 1.7 mg/L concentration.
- Executive summary:
Long term toxicity to fish was performed for 7 days at five different concentrations ranges from 1.0 to
25 mg/L. Four replicates of 10 P. promelas in 250 ml of test solution for each concentration were prepared and renewed daily. Fish were fed twice daily and mortality was observed daily. After 7 d of exposure, average weight per fish was calculated and compared to the control.
So, on the basis of above result the endpoint for benzylparaben (94-18-8) long term toxicity to P. promelas was found to be LOEC at 1.7 mg/L concentration.
Reference
Description of key information
Long term toxicity to fish was performed for 7 days at five different concentrations ranges from 1.0 to 25 mg/L. Four replicates of 10 P. promelas in 250 ml of test solution for each concentration were prepared and renewed daily. Fish were fed twice daily and mortality was observed daily. After 7 d of exposure, average weight per fish was calculated and compared to the control. So, on the basis of above result the endpoint for benzylparaben (94-18-8) long term toxicity to P. promelas was found to be LOEC at 1.7 mg/L concentration.
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 0.02 mg/L
Additional information
Various studies were reviewed along with the prediction data to evaluate the effect of the test compound on long term toxicity to fish. These are summarized as follows:
Long term toxicity to fish was performed for 7 days at five different concentrations ranges from 1.0 to 25 mg/L. Four replicates of 10 P. promelas in 250 ml of test solution for each concentration were prepared and renewed daily. Fish were fed twice daily and mortality was observed daily. After 7 d of exposure, average weight per fish was calculated and compared to the control. So, on the basis of above result the endpoint for benzylparaben (94-18-8) long term toxicity to P. promelas was found to be LOEC at 1.7 mg/L concentration.
Long term toxicity test was performed on fish for 14 days by the method Medaka vitellogenin test. After test it was found that the end point for the long term toxicity to fish for benzylparaben (94-18-8) was found to be 0.02 mg/l concentration.
Long term toxicity test was performed on fish for 7 days by the method Medaka vitellogenin test. After test it was found that the end point for the long term toxicity to fish for benzyl paraben (94-18-8) was found to be LOEC at 1.7mg/l concentration.
From above mentioned supporting studies the target chemical benzylparaben (CAS No 94-18-8), the majority values are indicative that the chemical is not likely to cause aquatic fish toxicity.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.