Registration Dossier
Registration Dossier
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EC number: 204-496-1 | CAS number: 121-73-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from peer reviewed article or handbook
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- SCREENING-LEVEL HAZARD CHARACTERIZATION Chloronitrobenzenes Category
- Author:
- U.S. Environmental Protection Agency
- Year:
- 2 012
- Bibliographic source:
- U.S. Environmental Protection Agency Hazard Characterization Document
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- Acute oral toxicity study was conducted to test the effects of m-chlorobenzene on rats and animals were observed for 14 days .Based on mortality the LD50 was determined.
- GLP compliance:
- not specified
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- 1-chloro-3-nitrobenzene
- EC Number:
- 204-496-1
- EC Name:
- 1-chloro-3-nitrobenzene
- Cas Number:
- 121-73-3
- Molecular formula:
- C6H4ClNO2
- IUPAC Name:
- 1-chloro-3-nitrobenzene
- Details on test material:
- - Name of test material (as cited in study report): 1-chloro-3-nitrobenzene
- Molecular formula (if other than submission substance): C6H4ClNO2
- Molecular weight (if other than submission substance): 165.191 g/mol
- Substance type: Solid
- Physical state: Organic
- Impurities (identity and concentrations): No data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Details on oral exposure:
- 14 days
- Doses:
- 0, 200, 251, 316, 398 or 501 mg/kg
- No. of animals per sex per dose:
- 5/sex/dose
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
Effect levels
- Key result
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 400 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: Mortalities were observed at 251, 316, 398 and 501 mg/kg.
- Mortality:
- Mortalities were observed at 251, 316, 398 and 501 mg/kg.
- Clinical signs:
- other: No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- LD50 was found to be 400mg/kg.
Test substance may be classified as acute toxicity catagory-4. - Executive summary:
Acute study is conducted to study the effect of the test substance onSprague-Dawley rats administered through gavage. The dose concentrations used were 0, 200, 251, 316, 398 or 501 mg/kg. Mortality was observed at 251, 316, 398 and 501 mg/kg.
The LD50was found to be 400mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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