Registration Dossier
Registration Dossier
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EC number: 210-441-2 | CAS number: 615-66-7
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- secondary literature
- Justification for type of information:
- Data is from secondary source.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- OPINION ON 2-Chloro-p-phenylenediamine COLIPA n° A8
- Author:
- European Cosmetics Toiletry and Perfumery Association (COLIPA)
- Year:
- 2 013
- Bibliographic source:
- Scientific Committee on Consumer Safety (SCCS), SCCS/1510/13, 19 September 2013
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study was conducted to evaluate the acute toxic effects of administration of 2-chloro-p-pheynelenediamine (CAS No. 615-66-7) in rats by the oral route.
- GLP compliance:
- not specified
- Test type:
- other: No data available
Test material
- Reference substance name:
- 2-chloro-p-phenylenediamine
- EC Number:
- 210-441-2
- EC Name:
- 2-chloro-p-phenylenediamine
- Cas Number:
- 615-66-7
- Molecular formula:
- C6H7ClN2
- IUPAC Name:
- 2-chlorobenzene-1,4-diamine
- Details on test material:
- - Name of test material (as cited in study report): 2-Chloro-p-phenylenediamine
- Molecular formula (if other than submission substance): C6H7N2Cl
- Molecular weight (if other than submission substance): 142.588 g/mole
- Substance type: Organic
- Physical state: Solid
- Purity 99%
- Impurities (identity and concentrations): 1 %
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data available
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Details on oral exposure:
- No data available
- Doses:
- No data available
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- No data available
- Statistics:
- No data available
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 729 mg/kg bw
- Based on:
- test mat.
Applicant's summary and conclusion
- Interpretation of results:
- other: Category 4 based on CLP criteria
- Conclusions:
- The acute oral median lethal dose (LD50) of 2-chloro-p-phenylenediamine in rat was observed to be 729 mg/kg bw.
- Executive summary:
The study was conducted to evaluate the acute toxic effects of administration of 2-chloro-p-pheynelenediamine (CAS No. 615-66-7) in rats by the oral route. The acute oral median lethal dose (LD50) of 2-chloro-p-phenylenediamine in rat was observed to be 729 mg/kg bw. Thus, according to CLP criteria for acute toxicity rating for the chemicals, it infers that 2-chloro-p-phenyl enediamine (CAS No. 615-66-7) can be classify under category 4 compound at the tested dose levels.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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