Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 237-525-1 | CAS number: 13826-35-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Data is from online Chemical Repository Database
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Acute Dermal Toxicity (LD50) Study in the Albino Rabbit assess for 14 days.
- GLP compliance:
- not specified
- Test type:
- other: Acute toxic class method
Test material
- Reference substance name:
- 3-phenoxybenzylic alcohol
- EC Number:
- 237-525-1
- EC Name:
- 3-phenoxybenzylic alcohol
- Cas Number:
- 13826-35-2
- Molecular formula:
- C13H12O2
- IUPAC Name:
- (3-phenoxyphenyl)methanol
- Test material form:
- other: liquid
- Details on test material:
- - Name of test material (as cited in study report): 3-Phenoxybenzyl alcohol
- Molecular formula (if other than submission substance): C13H12O2
- Molecular weight (if other than submission substance): 200.23318 g/mol
- Smiles notation (if other than submission substance): C1=CC=C(C=C1) OC2=CC=CC (=C2) CO
- InChl (if other than submission substance): InChI=1S/C13H12O2/c14-10-11-5-4-8-13(9-11)15-12-6-2-1-3-7-12/h1-9, 14H, 10H2
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Kuiper's Rabbit Ranch, Gary, Indiana
- Age at study initiation: No data available
- Weight at study initiation: 2318 to 2925 grams
- Fasting period before study: No data available
- Housing: housed in hanging wire-mesh cages in temperature and humidity controlled quarters
- Diet (e.g. ad libitum): Purina Rabbit Chow(ad libitum)
- Water (e.g. ad libitum): ad libitum
- Acclimation period: No data available
ENVIRONMENTAL CONDITIONS
- Temperature (°C): temperature controlled quarters(°C not mention)
- Humidity (%): humidity controlled quarters (% not mention)
- Air changes (per hr): No data available
- Photoperiod (hrs dark / hrs light): No data available
IN-LIFE DATES: From: To: No data available
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- MAXIMUM DOSE VOLUME APPLIED: 20000 mg/kg.
- Doses:
- 2500, 5000, 10000 and 20000 mg/kg.
- No. of animals per sex per dose:
- 8 male and 8 female
- Control animals:
- yes
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Frequency: They were observed at 24 hours and daily thereafter for a total of 14 days for pharmacotoxic signs and dermal irritation
Weighing: Body weights were measured initially and at 7 and 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: body weight, gross necropsy. - Statistics:
- No data available
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 6 702 - 14 921
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 000 - 20 000
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 10 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 5 000 - 20 000
- Other findings:
- Pharmacotoxic signs were observed during the 14-day observation period as hypo activity, decrease limb tone, ataxia, dehydration, emaciation etc.
Any other information on results incl. tables
Mortality:
Dosage level(mg/kg) |
Total Mortalities |
||
Male |
Female |
Total |
|
2500 |
0/2 |
0/2 |
0/4 |
5000 |
0/2 |
0/2 |
0/4 |
10000 |
1/2 |
1/2 |
2/4 |
20000 |
2/2 |
2/2 |
4/4 |
Clinical signs:
Days |
Erythema |
Edema |
Atonia |
Desquamation |
|||||||||
None |
Very slight |
slight |
moderate |
None |
Very slight |
slight |
None |
Very slight |
slight |
None |
Very slight |
slight |
|
1-3 |
|
|
2/4 |
2/4 |
2/4 |
|
2/4 |
4/4 |
|
|
4/4 |
|
|
4* |
|
|
3/3 |
|
|
2/3 |
1/3 |
1/3 |
|
2/3 |
3/3 |
|
|
5 |
1/3 |
|
2/3 |
|
2/3 |
|
1/3 |
1/3 |
|
2/3 |
3/3 |
|
|
6** |
1/2 |
|
1/2 |
|
2/2 |
|
|
1/2 |
|
1/2 |
1/2 |
|
1/2 |
7 |
1/2 |
1/2 |
|
|
2/2 |
|
|
|
1/2 |
1/2 |
|
|
2/2 |
8 |
2/2 |
|
|
|
2/2 |
|
|
1/2 |
|
1/2 |
|
|
2/2 |
9 |
2/2 |
|
|
|
2/2 |
|
|
1/2 |
|
1/2 |
|
1/2 |
1/2 |
10 |
2/2 |
|
|
|
2/2 |
|
|
1/2 |
1/2 |
|
|
1/2 |
1/2 |
11-14 |
2/2 |
|
|
|
2/2 |
|
|
2/2 |
|
|
|
|
2/2 |
*1 of 4 rabbits dead. **2 of 4 rabbits dead. |
|||||||||||||
|
Body weight:
The following body weights were obtained during the 14-day observation period:
Dosage level(mg/kg) |
Individual Rabbit no. |
Sex |
Control Weight |
7 day weights |
14 day weights |
10000 |
31683 |
Male |
2642 |
2050 |
2427 |
|
31685 |
Male |
2583 |
Died |
Died |
|
31710 |
Female |
2731 |
2363 |
2612 |
|
31714 |
Female |
2768 |
Died |
Died |
Gross pathology:
Rabbits which were scarified following 14 days of observations.
Number Exhibiting Sign/Number necropsied
Dosage Level (mg/kg)
|
2500 |
5000 |
10000 |
|||
Male |
Female |
Male |
Female |
Male |
Female |
|
No gross lesions |
2/2 |
1/2 |
2/2 |
1/2 |
1/1 |
1/1 |
Stomach, green fluid contents |
|
1/2 |
|
|
|
|
Stomach mucosa, dark red foci |
|
1/2 |
|
|
|
|
Spleen, pale coloration |
|
|
|
1/2 |
|
|
Sub-lumbar region, two areas of necrotic fat |
|
1/2 |
|
|
|
|
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD 50 value for the New Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg.
- Executive summary:
Acute toxicity test (Dermal) inNew Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was performed.
8 Male and 8 female animals were used for the study at 2500, 5000, 10000 and 20000 mg/kg.They were individually housed in hanging wire-mesh cages in temperature and humidity controlled quarters.The rabbits weighed from 2318 to 2925 grams at the beginning of the study.Body weights were measured initially and at 7 and 14 days.They were maintained in accordance with the recommendations contained in H.E.W. Publication No. 74-23 (N.L.H.) entitled "Guide for the Care and Use of Laboratory Animals.
The hair was removed from the back of each rabbit. The skin of one male and one female in each group was abraded with a scalpel blade.The test material was applied once only to the backs of the rabbits. The area wrapped with gauze bandaging and occluded with Saran Wrap and observed for 14 days. Gross necropsy was done if some rabbits were died during 14 days and at the end of 14 days.
From the above study and observations, the LD 50 value for the New Zealand white rabbits by 3-Phenoxybenzylalcohol (CAS No: 13826-35-2) was found to be 10000 mg/kg.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.