Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 224-618-7 | CAS number: 4430-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on developmental toxicity
Description of key information
According to the results of the two availables key studies (GLP, Klimisch 1, Following OECD guideline 414 method) and the CLP regulation, the registered substance Jarocol Violet 43 was considered to have a No Observe Adverse Effect Level for developmental toxicity (NOAEL) at 800 mg/kg/day (test material) by oral gavage routes (studies performed on rats).
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 800 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- NOAEL
- 800 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
Two studies were available for teratogenicity of registered substance assessment. They were considered as key studies. These two studies are teratogenicity studies performed on two different rat strains according the OECD guideline 414 method :
- The first key study (Klimisch 1, GLP, OECD 414, 1994) was performed on Sprague Dawley female rats which were exposed orally by gavage to 0, 50, 200 and 800 mg/kg/day of substance in water during day 6 to 15 of gestation period.
-The second key study (Klimisch 1, GLP, OECD 414, 2000) was performed on Wistar female rats which were exposed orally by gavage to 0, 100, 300 and 1000 mg/kg/day of substance in 1% carboxymethyl cellulose during day 6 to 17 of gestation period.
In the two studies, no adverse effect was observed in the fetuses or the pregnant rats. No abnormality or malformation was noted in both key studies. The NOAEL values were respectively defined as high dose level used in each study (respectively 800 and 1000 mg/kg bw/day).
Justification for classification or non-classification
In the two studies, no adverse effect was observed in the fetuses or the pregnant rats. No abnormality or malformation was noted in both key studies. The NOAELs were respectively defined as 800 and 1000 mg/kg/day in each study.
According to the results of the two availables key studies (GLP, Klimisch 1, Following OECD guideline 414 method) and the CLP regulation, the test substance was considered to have a No Observe Adverse Effect Level (NOAEL) for developmental toxicity at 800 mg/kg/day (test material) by gavage route (studies performed on rats).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.