Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 235-115-7 | CAS number: 12069-89-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 1990-06-25 to 1990-11-02
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study. Sodium molybdate is used as read-across partner to Dimolybdenum carbide.
Data source
Reference
- Title:
- Unnamed
- Year:
- 1 990
- Report date:
- 1990
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium molybdate
- IUPAC Name:
- Sodium molybdate
- Reference substance name:
- 7631-95-0
- Cas Number:
- 7631-95-0
- IUPAC Name:
- 7631-95-0
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Sodium molybdate
- Physical state: white crystalline powder
- Analytical purity: 46.03 % Molybdenum, 18.69% sodium
- Purity test date: 1990-06-06
- Storage condition of test material: at room temperature
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: A. Smith, Warlingham, Surrey and Froxfield Farms (U.K.) Ltd., Petersfield, Hampshire
- Age at study initiation: 11 to 13 weeks
- Weight at study initiation: 2.6 to 3.0 kg
- Housing: individually in metal cages with perforated floors
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 19 °C
- Humidity (%): 30 to 70 %
- Air changes (per hr): 19
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 100 mg of Sodium molybdate (the weight occupying a volume of 0.1 mL) - Duration of treatment / exposure:
- A 100 mg amount of the test item was placed into the lower everted lid of one eye of each animal. The eyelids were then gently held together for one second before releasing. The contralateral eye remained untreated and served as a control.
- Observation period (in vivo):
- 1, 24, 48, 72, 96 and 168 hours
- Number of animals or in vitro replicates:
- 6 (4 males and 2 females)
- Details on study design:
- SCORING SYSTEM:
Cornea:
Opacity: degree of density (area most dense taken for reading)
0 - No ulceration or opacity
1 - Scattered or diffuse areas of opacity (other than slight dulling of normal lustre), details of iris clearly visible
2 - Easily discernible translucent areas, details of iris slightly obscured
3 - Nacrous areas, no details of iris visible, size of pupil barely discernible
4 - Opaque cornea, iris not discernible through the opacity
Area of cornea involved
1 - One quarter (or less) but not zero
2 - Greater than one quarter, but less than half
3 - Greater than half, but less than three quarter
4 - Greater than three quarters, up to whole area
Iris
0 - Normal
1 - Markedly deepened rugae, congestion, swelling, moderate circumcorneal hyperaemia or injection, any of these or combination of any thereof, iris still reacting to light (sluggish reaction is positive)
2 - No reaction to light, haemorrhage, gross destruction (any or all of these)
Conjunctivae
Redness (refers to palpebral and bulbar conjunctivae cornea and iris)
0 - Blood vessels normal
1 - Some blood vessels definitely hyperaemic (injected)
2 - Diffuse, crimson colour, individual vessels not easily discernible
3 - Diffuse, beefy red
Chemosis (lids and/or nictating membranes)
0 - No swelling
1 - Any swelling above normal (includes nictitating membranes)
2 - Obvious swelling with partial eversion of lids
3 - Swelling with lids about half-closed
4 - Swelling with lids more than half-closed
TOOL USED TO ASSESS SCORE:
handheld torch
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- iris score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 0
- Irritation parameter:
- conjunctivae score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 0.66
- Reversibility:
- fully reversible within: 3d
- Irritation parameter:
- chemosis score
- Basis:
- mean
- Time point:
- 24/48/72 h
- Score:
- 0.06
- Max. score:
- 0.33
- Reversibility:
- fully reversible within: 2d
Any other information on results incl. tables
Table 1: Mean values of each rabbit scored at 24, 48 and 72 hours after treatment with Sodium molybdate | |||||||||
Animal number | Opacity | Iritis | Conjunctival redness | Conjunctival oedema | |||||
2451 (male) | 0 | 0 | 0.33 | 0 | |||||
2523 (male) | 0 | 0 | 0.33 | 0 | |||||
2524 (male) | 0 | 0 | 0.66 | 0.33 | |||||
2525(male) | 0 | 0 | 0.33 | 0 | |||||
2526 (female) | 0 | 0 | 0 | 0 | |||||
2527 (female) | 0 | 0 | 0.33 | 0 | |||||
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Criteria used for interpretation of results: EU
- Conclusions:
- In conclusion, in an acute eye irritation/corrosion study according to OECD 405, the read-across partner Sodium molybdate is not an eye-irritant.
- Executive summary:
In a primary eye irritation study (OECD 405), 100 mg of Sodium molybdate was instilled into the conjunctival sac of one eye of each of six young adult New Zealand White rabbits (four males and two females). Animals were observed for 7 days. Irritation was scored by the method of Draize. Only very mild conjunctival reactions were observed, which were fully reversible within 2-3 days. In this study, Sodium molybdate is not an eye irritant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.