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EC number: 434-630-6 | CAS number: 60372-77-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Adsorption / desorption
Administrative data
Link to relevant study record(s)
- Endpoint:
- adsorption / desorption
- Remarks:
- adsorption
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From January 10, 2000 to February 16, 2001
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Guideline study with GLP.
- Qualifier:
- according to guideline
- Guideline:
- other: OECD Draft Document TGP/94.75
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: OECD draft document TG/Adsorpti/97.94 (July 1997)
- Deviations:
- no
- GLP compliance:
- yes
- Type of method:
- HPLC estimation method
- Media:
- soil
- Test temperature:
- Ambient 18.5ºC
- Details on study design: HPLC method:
- EQUIPMENT
- Autosampler: Model ISS200, Perkin Elmer
- Pump: Model 510, Waters Associates
- Detection system: Model Lambda Max 481, Waters Associates
- Column: Apex cyano, 5µm, 25 cmx4.6 mm i.d.
MOBILE PHASES
- Type: Methanol/water, 50/50 v/v
- Flow rate: 1.0 ml/min
- Solutes for dissolving test and reference substances: Methanol
DETERMINATION OF DEAD TIME
- Method: by means of homologous series
REFERENCE SUBSTANCES
- Identity: Thiourea, Monolinuron, Triadimenol, Triadimefon, Azinphos Methyl, Pyrazophos and Sulprofos.
DETERMINATION OF RETENTION TIMES
- Quantity of test substance introduced in the column: 81.229 µg
- Quantity of reference substances: thiourea (14.290 mg/l); monolinuron (102.34 mg/l); triadimenol (99.900 mg/l); triadimefon (142.44 mg/l); azinphos methyl (45.900 mg/l); pyrazophos (127.06 mg/l) and sulprofos (53.590 mg/l)
REPETITIONS
- Number of determinations: 2
EVALUATION
- Calculation of capacity factors k': 6.449
- Calculation of retention times: 22.275 minutes
- Determination of the log Koc value: 1.76 - Analytical monitoring:
- yes
- Key result
- Type:
- log Koc
- Value:
- 1.76
- Temp.:
- 18.5 °C
- Remarks on result:
- other: calculated: log koc= 0.52*log kow+1.02
- Key result
- Type:
- Koc
- Value:
- 58
- Temp.:
- 18.5 °C
- Details on results (HPLC method):
- - Retention times of reference substances used for calibration: Thiourea (2.990); Monolinuron (5.260); Triadimenol (6.305); Triadimefon (6.945); Azinphos Methyl (8.020); Pyrazophos (12.030); Sulprofos (27.405);
- Details of fitted regression line (log k' vs. log Koc): Slope: 0.38234; Intercept: -0.85667; Correlation coefficient: 0.99071
- Average retention data for test substance: 22.275 - Conclusions:
- The test substance would be expected to be mobile in soils.
- Executive summary:
The soil adsorption coefficient was determined by the HPLC method as described in OECD Draft document TGP/94.75 (April 1994) and subsequently in OECD Draft document TG/Adosorpti/97.94 (July 1997). The soil adsorption coefficient obtained experimentally in this study is considered as very high when compared against the partition coefficient (shake flask method). It is therefore considered more appropriate to use a calculation method for this material. The recommended formula for a nonhydrophobic material is log koc= 0.52*log kow+1.02. Using the measured log kow value of 1.43 gives a log koc result of 1.76 and a soil adsorption coefficient of 58.0.
The soil adsorption coefficient of Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) was calculated: Koc = 58.0 at 18.5 ºC. Therefore the test substance would be expected to be mobile in soils.
Reference
Table 1. Experimental results of Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (L.A.E):
Test |
Retention time (min) |
Mean retention time (min) |
K |
log k |
log Koc |
Koc |
1 |
22.42 |
22.275 |
6.4495 |
0.80955 |
4.3583 |
22819 |
2 |
22.13 |
Description of key information
Key study: Test method according to OECD Draft document TGP/94.75 (April 1994) and OECD Draft document TG/Adsorption/97.75 (July 1997). The soil adsorption coefficient of Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (L.A.E) was calculated: Koc = 58.0 at 18.5 ºC. Therefore the Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (L.A.E) would be expected to be mobile in soils.t method according to OECD.
Key value for chemical safety assessment
- Koc at 20 °C:
- 58
Additional information
- Key study 1:
The soil adsorption coefficient was determined by the HPLC method as described in OECD Draft document TGP/94.75 (April 1994) and subsequently in OECD Draft document TG/Adsorpti/97.94 (July 1997).The soil adsorption coefficient obtained experimentally in this study is considered as very high when compared against the partition coefficient (shake flask method). It is therefore considered more appropriate to use a calculation method for this material. The recommended formula for a nonhydrophobic material is log koc= 0.52*log kow+1.02. Using the measured log kow value of 1.43 gives a log koc result of 1.76 and a soil adsorption coefficient of 58.0. The soil adsorption coefficient of Nα-Lauroyl-L-arginine ethyl ester monohydrochloride (LAE) was calculated: Koc = 58.0 at 18.5 ºC. Therefore the test substance would be expected to be mobile in soils.
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