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EC number: 609-051-9 | CAS number: 35000-37-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP Study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 008
- Report date:
- 2008
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
Test material
- Reference substance name:
- [2-(tert-butoxy)-2-oxoethyl]triphenylphosphanium chloride
- EC Number:
- 609-051-9
- Cas Number:
- 35000-37-4
- Molecular formula:
- C24H26ClO2P
- IUPAC Name:
- [2-(tert-butoxy)-2-oxoethyl]triphenylphosphanium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- Species: Rat, Wistar strain Cri:WI(Han) (outbred, SPF-Quality). Recognised by international guidelines as the recommended test system (e.g. OECD, EC).
Number of animals: 18 Females (nulliparous and non-pregnant). Each dose group consisted of 3 animals.
Age and body weight: Young adult animals (approx. 8-11 weeks old) were selected. Body weight variation did not exceed +/- 20% of the sex mean.
Identification: Earmark.
Health inspection: A health inspection was performed prior to commencement of treatment, to ensure that the animals were in a good state of health.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 2000 mg/kg (1 0 mL/kg) body weight.
300 mg/kg (1 0 mL/kg) body weight.
50 mg/kg (1 0 mL/kg) body weight.
5 mg/kg (10 mL/kg) body weight. - No. of animals per sex per dose:
- 18 Females (nulliparous and non-pregnant). Each dose group consisted of 3 animals.
- Control animals:
- no
- Details on study design:
- The toxicity of the test substance was assessed by stepwise treatment of groups of 3 females. The first group was treated at a dose level of
2000 mg/kg. The absence or presence of mortality of animals dosed at one step determined the next step, based on the test procedure
defined in the guidelines. The onset, duration and severity of the signs of toxicity were taken into account for determination of the time
interval between the dose groups.
Results and discussion
Effect levels
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 5 - < 50 mg/kg bw
- Mortality:
- 2000 mg/kg: 3/3
300 mg/kg: 3/3
50 mg/kg: 0/3
50 mg/kg: 2/3
5 mg/kg: 0/3
5 mg/kg: 0/3
The decedents at 2000 mg/kg were found dead within 1 minute post-treatment and the decedents at 300 mg/kg were found within 5 minutes post-treatment. The decedent and moribund animal at 50 mg/kg were found between days 2 and 4 post-treatment. - Clinical signs:
- other: 2000 mg/kg: No symptoms were noted in the time span of less than 1 minute between treatment and death. 300 mg/kg: Clonic spasms, hunched posture, uncoordinated movements, flat gait, quick breathing, salivation, moribund. 50 mg/kg: Lethargy, hunched or fla
- Gross pathology:
- No abnormalities were found at macroscopic post mortem examination of the animals.
- Other findings:
- None
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category II
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The oral LD50 value of DCM in female Wistar rats was established to be within the range of 5-50 mg/kg body weight.
According to the OECD 423 test guideline the LD50 cut-off value was considered to be 50 mg/kg body weight.
Based on these results:
- according to the Globally Harmonized System of Classification and Labelling of Chemicals (GHS) of the United Nations (2004), DCM should
be classified as: fatal if swallowed (Category 2) for acute toxicity by the oral route.
- according to the EC criteria for classification and labelling requirements for dangerous substances and preparations (Council Directive 67/548/ EEC), DCM should be labelled as: toxic if swallowed (R25).
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