Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 204-062-1 | CAS number: 115-07-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
There is no evidence of carcinogenicity of propene following evaluation in 2 rat and 2 mouse strains.
Key value for chemical safety assessment
Carcinogenicity: via oral route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Carcinogenicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Carcinogenicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Propene was not carcinogenic in near-guideline tests (NTP, 1985), no classification is warranted under DSD or CLP.
Additional information
Propene did not produce cancer in lifetime tests in 2 strains of each rat and mouse (F344 rat & B6C3F1 mouse by NTP, 1985), (Sprague-Dawley rat & Swiss mouse by Ciliberti et al.,1988). Of the two groups of studies reported, those conducted by NTP are more fully reported and therefore have been selected as the key studies of carcinogenicity.
Key 2-year Toxicity Studies, NTP
Based on the risk of explosion that can occur at high propene concentrations, the highest dose level considered safe for use in these studies was 10,000 ppm (17,200 mg/m3). Groups of 50 F344/N rats of each sex were exposed to propene in air (98.6% - 99.7% pure) by inhalation at concentrations of 5,000 or 10,000 ppm, (8,600 or 17,200 mg/m3) 6 hours per day, 5 days per week, for 103 weeks. Other groups of 50 rats of each sex received air only on the same schedule and served as chamber controls. The survival of exposed and control rats was comparable.
B6C3F1 mice (50 males and 49-50 females/group) were also exposed to propene in air (98.6% - 99.7% pure) by inhalation at concentrations of 5,000 or 10,000 ppm, (8,600 or 17,200 mg/m3) 6 hours per day, 5 days per week, for 103 weeks. Other groups of 50 mice of each sex received air only on the same schedule and served as chamber controls. The survival of exposed and control mice was comparable.
Complete necropsy and histopathology examination was performed on all animals.
There was no evidence of carcinogenicity in male and female F344/N rats or in male and female B6C3F1 mice exposed to propene by inhalation at concentrations of 5000 or 10000 ppm (8,600 or 17,200 mg/m3), for 103 weeks (NTP, 1985), or in the supporting study in male and female Swiss mice at concentrations up to 5000 ppm (8,600 mg/m3), following exposure for 78 weeks, or in male and female Sprague-Dawley rats at concentrations up to 5000 ppm (8,600 mg/m3), following exposure for 104 weeks (Ciliberti et al, 1988).
Oral and dermal routes of exposure are not relevant for a gas.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.