Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Insufficient experimental detail to assess quality.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 972
Materials and methods
- Principles of method if other than guideline:
- 5 rats received single application of 1 mL/kg isoprene each on their back skin (animals had been shaved the day before application). The substance was not removed for 7 days.
- GLP compliance:
- no
- Test type:
- fixed dose procedure
- Limit test:
- no
Test material
- Reference substance name:
- Isoprene
- EC Number:
- 201-143-3
- EC Name:
- Isoprene
- Cas Number:
- 78-79-5
- Molecular formula:
- C5H8
- IUPAC Name:
- 2-methylbuta-1,3-diene
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- weight 160-210 g
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 1 mL/kg bw
- Remarks on result:
- other: >679 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- An acute dermal LD50 of >1 mL/kg bw was established.
- Executive summary:
5 rats received single application of 1 mL isoprene each on their back skin (animals had been shaved the day before application). The substance was not removed for 7 days.
An acute dermal LD50 of >1 mL/kg bw (>679 mg/Kg bw) was established.
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