Registration Dossier
Registration Dossier
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EC number: 201-143-3 | CAS number: 78-79-5
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
The 48 hour EC50 for acute toxicity to aquatic invertebrates is 5.77 mg/L. TLM QSAR modelling was used to calculate the LL50 value of isoprene towards D. Magna. The calculated LL50 value is 32.098 mg/L.
The lowest value was used for chemical safety assessment.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 5.77 mg/L
Additional information
Huntingdon Life Science (2004) reports a 48-hour EC50 value of 5.77 mg/L for Daphnia magna in a standard OECD TG 202 test. This result was from a static study with analytical confirmation of the exposure concentrations. The result is based on the mean of measured exposure concentrations. This study was conducted under GLP to standard guidelines. It was listed as Klimisch 1 in the OECD SIDS for isoprene and was also used by the Olefins Panel of the American Chemistry Council in the Category Summary for C5 non-cyclics for the US High Production Volume Chemical Program. Additional data are available regulatory documents and QSARs for isoprene.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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