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Diss Factsheets
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EC number: 203-572-1 | CAS number: 108-32-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation / corrosion: Two reliable studies were available for this endpoint (one Klimisch 1 and one Klimisch 2). The study of Mallory (1985) was considered to be the key study. Based on this study, propylene carbonate should not be classified as irritating to the skin.
Eye irritation: Four reliable studies were available (four Klimisch 1 studies). Johnson (2001) was chosen as the key study. Based on this study, propylene carbonate is classified as irritating to eyes (category 2).
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation / corrosion:
Mallory (1985) studied skin corrosion and skin irritation by applying propylene carbonate on the trunk of 6 New Zealand White rabbits in occlusive conditions (shaved and abraded skin), according to OECD guideline 404. Exposure lasted for 24 hours and observations were performed at 24 and 72 hours. Lesions were scored according to the Draize system and a primary dermal irritation index of 0.2 was calculated. After 72 hours all animals appeared normal.
No in vitro skin corrosion/irritation study is performed as reliable in vivo data was already available.
Eye irritation:
Johnson (2001) investigated the eye irritation effects of 0.1 mL ULTRAPURE propylene carbonate in 3 male New Zealand White rabbits (1 to 2 seconds of exposure). The study was performed according to OECD guideline 405, EU Method B.5 and EPA OPPTS 870.2400.
According to the criteria laid down in the CLP Regulation (EC) 1272/2008, propylene carbonate is classified as an eye irritant substance category 2 (irritating to eyes) as the mean redness score is 2 at 24, 48 and 72 hours in 2 of the 3 animals tested and the effects are fully reversible within 10 days. This study was designated as key study as the most pure grade was tested: 100% propylene carbonate. Other studies on eye irritation were performed with reagent grade of propylene carbonate.
No in vitro eye corrosion/irritation study is performed as reliable in vivo data was already available. Moreover, the study does not need to be conducted as the available information indicates that the criteria are met for clasification as irritating to eyes.
Justification for classification or non-classification
According to the criteria laid down in the CLP (EC) Regulation 1272/2008, propylene carbonate should not be classified as irritating to the skin.
Based on the available data and according to the criteria laid down in the CLP Regulation (EC) 1272/2008, propylene carbonate is classified as an eye irritant substance category 2 (irritating to eyes).
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