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EC number: 237-066-7 | CAS number: 13598-36-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- January 1977
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP study, and no OECD Guideline followed. Acceptable basic data.
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: U.N. Transport Regulations; U.S. Federal Regulations
- Deviations:
- not specified
- GLP compliance:
- no
Test material
- Reference substance name:
- Phosphonic acid
- EC Number:
- 237-066-7
- EC Name:
- Phosphonic acid
- Cas Number:
- 13598-36-2
- Molecular formula:
- H3O3P
- IUPAC Name:
- phosphonic acid
- Reference substance name:
- Phosphorous acid
- EC Number:
- 233-663-1
- EC Name:
- Phosphorous acid
- Cas Number:
- 10294-56-1
- IUPAC Name:
- phosphorous acid
- Details on test material:
- - Name of test material (as cited in study report): Phosphorous acid
- Physical state: Liquid
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Bantin and Kingman Ltd.
- Age at study initiation: no data
- Weight at study initiation: 2-3 kg
- Housing: one animal per cage
- Diet: standard rabbit diet
- Water: ad libitum
- Acclimation period: no data
ENVIRONMENTAL CONDITIONS: no data
IN-LIFE DATES: no data
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- not specified
- Controls:
- no
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 ml
- Concentration (if solution): 80% - Duration of treatment / exposure:
- 4 hours
- Observation period:
- 3 minutes, 1, 4, 24, and 48 hours
- Number of animals:
- 3 males and 3 females
- Details on study design:
- TEST SITE
- Area of exposure: back
- % coverage: 1 inch square
- Type of wrap if used: the patch was covered with an overlapping patch of impermeable plastic adhesive tape. After the final application, the entire trunk was bound with Sleek occlusive tape.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): gently cleansed with water
- Time after start of exposure: 4 hours
SCORING SYSTEM: FDA scoring system, simlar to Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- edema score
- Basis:
- animal: #1,3 and 5
- Time point:
- 24 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Complete breakdown of skin with bleeding - rabbit sacrificed
- Irritation parameter:
- erythema score
- Basis:
- animal: #1,3 and 5
- Time point:
- 24 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Complete breakdown of skin with bleeding -rabbit sacrificed
- Irritation parameter:
- edema score
- Basis:
- animal: #2,4 and 6
- Time point:
- 24 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- not reversible
- Irritation parameter:
- edema score
- Basis:
- animal: #2, 4 and 6
- Time point:
- 24 h
- Score:
- > 4
- Max. score:
- 4
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Dark red brown area
- Irritation parameter:
- primary dermal irritation index (PDII)
- Basis:
- animal: All
- Time point:
- other: 48/72h
- Reversibility:
- not reversible
- Remarks on result:
- not determinable
- Remarks:
- Substance corrosive, all animals were sacrificed
- Irritant / corrosive response data:
- At the 1 h reading visible necrosis of the skin was only evident in 2 of the 6 sites treated with this material. However at the 4 h reading all sites treated with phosphorous acid (80%) showed visible necrosis. Visible necrosis was evident at all treated
sites after contact of more than 3 and up to 60 minutes. It was impossible to calculate the primary irritation scores for the materials since for humane reasons the rabbits were sacrificed before the required 72 h reading could be taken.
Any other information on results incl. tables
Oedema mean score (6 rabbits) |
Erythema/Eschar mean score (6 rabbits) |
|
3 minutes | 0 | 0.25 |
1 hour | 0.83 | 2 rabbits visible necrosis |
4 hours | 2 | all 6 rabbits dark red brown area |
24 hours | 3 rabbits dark red brown, and 3 rabbits complete breakdown of skin with bleeding; 4 rabbits sacrificed | |
48 hours | 2 rabbis left: blackened skin, but minimal breakdown |
Applicant's summary and conclusion
- Interpretation of results:
- other: Cat.1A Corrosive
- Remarks:
- based on CLP 67/548/EEC and 1272/2008.
- Conclusions:
- Phosporous acid (80%) caused visible necrosis at 2 sites after contact for 3-60 minutes in 2 of the 6 sites. The remaining 4 sites showed necrosis after contact of more than 1 hour and up to 4 hours. Based on these results and according to EU criteria Phosporous acid (80%) was considered to be corrosive and the material needs to be classified as Cat.1A Corrosive according to the classification criteria outlined in 67/548/EEC and 1272/2008.
- Executive summary:
A skin corrosion study was conducted, according to U.N. Transport Regulations and U.S. Federal Regulations on 3 male and 3 female New Zealand White rabbits using the test material Phosporous acid (80%). 0.5 ml of the test material was applied under occlusion to the shaved backs of the 6 rabbits. Patch application was repeated after 3 minutes and 1 hour. The test material was not applied at further treatments after 4 hours. Observations for dermal irritation or defects were made at 3 minutes, and 1, 4, 24, and 48 hours after application of the test material. Phosporous acid (80%) caused visible necrosis at 2 sites after contact for 3-60 minutes in 2 of the 6 sites. The remaining 4 sites showed necrosis after contact of more than 1 hour and up to 4 hours. It was impossible to calculate the primary irritation score, since for humane reasons the rabbits were sacrificed before the required 72 hours reading could be taken. Based on these results and according to EU criteria Phosporous acid (80%) was considered to be corrosive and the material needs to be classified as corrosive according to the classification criteria outlined in 67/548/EEC and 1272/2008.
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