Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 267-053-1 | CAS number: 67784-78-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented and reported study, conducted according to internationally accepted technical guidelines and in compliance with GLP in recognized contract research organization. Fully adequate for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.1 tris (Acute Oral Toxicity - Acute Toxic Class Method)
- Version / remarks:
- of 1996
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- of 1996
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Wistar rats, strain: Crl:(WI) BR (outbred, SPF-Quality) with appropriate range of bodyweight at study start.
Females were nulliparous and non-pregnant.
- Source: Charles River Deutschland, Sulzfeld, Germany.
- Age at study initiation (day of dosing): Approx. 7 weeks.
- Weight at study initiation (day of dosing): Males: mean: 255 g, minimum 252 g, maximum 260 g
Females: mean: 177 g, minimum 170 g, maximum 181 g.
- Fasting period: Overnight (for a maximum of 20 hours) prior to dosing until 3-4 hours post administration.
Water was available.
- Housing: Group housing with 3 animals/Macrolon type IV cage.
- Diet (ad libitum): Commercially available standard pelleted laboratory animal diet (from Altromin, code VRF 1).
- Water (ad libitum): Tap water
- Acclimation period: At least 5 days before start of dosing under laboratory conditions.
ENVIRONMENTAL CONDITIONS
Animals were housed in a controlled environment with optimal conditions considered to be approximately 15 air changes per hour, 21±3°C, 30-70% relative humidity, and 12 hours artificial fluorescent light and 12 hours darkness per day.
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- DOSE VOLUME APPLIED:
A dose volume of 1.68 mL unchanged test substance per kg bodyweight was administered by oral gavage. In view of a specific gravity of 1.19, the administered dose volume corresponds to a dose of 2000 mg unchanged test substance per kg body weight.
CLASS METHOD - Rationale for the selection of the starting dose:
Starting at the limit dose of 2000 mg/kg, in retrospect, proved to be appropriate, as no animals died at this dose. - Doses:
- 2000 mg/kg bw (3 males + 3 females)
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- Post-dosing observation period was 14 days during which mortality/survival and clinical signs were recorded at: 0, 2 and 4 hours after dosing on day 1 and twice daily (mortality/survival) or once daily (clinical signs) thereafter until day 15. Body weight of each animal was recorded on day 1 (prior to dosing) and on days 8 and 15. At the end of the 14-day post-dosing observation period (day 15), all animals were killed by asphyxiation with oxygen/carbon dioxide and necropsied. Macroscopic pathology findings were recorded.
- Statistics:
- Not applicable, as there were no deaths and only one dose group. In addion, the acute toxic class method is not intended for the calculation of a precise LD50 value.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Remarks on result:
- other: No deaths at the limit dose of 2000 mg/kg
- Mortality:
- Dose level Mortality Date of treatment
2000 mg/kg 0/3 (f) 09 January 2001
2000 mg/kg 0/3 (m) 11 January 2001 - Clinical signs:
- other: Clinical signs of systemic toxicity were not evident.
- Gross pathology:
- Necropsy of each animal at the end of the 14-day post treatment observation period did not reveal any macroscopic pathology findings.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information no mortality at the limit dose of 2000 mg/kg Criteria used for interpretation of results: EU
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)
Bien que l'ECHA fournisse énormément de matériel en ligne dans votre langue, une partie de cette page n'est disponible qu'en anglais. De plus amples informations sur la pratique multilingue de l'ECHA sont disponibles.
Bienvenue sur le site web de l'ECHA. Ce site n'est pas entièrement compatible avec Internet Explorer 7 (ni avec les versions antérieures). Veuillez mettre à jour Internet Explorer.
Ce site web utilise des cookies afin de vous garantir la meilleure expérience possible sur nos sites web.
Pour en savoir plus sur la façon dont nous utilisons les cookies.