Pentanedioic acid, compd. with (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol (1:1)

Additional physico-chemical information

Description of key information

Studies conducted on the  substance of interest Abacavir Glutarate

Minimum ignition temperature-powder layer: No ignition or exotherm observed up to 400°C

Studies conducted on the  analogue substance Abacavir Hemisulphate

Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996): Minimum ignition temperature of dispersed dust was determined to be 570°C.

Minimum Ignition Energy Measurement - (Weaver, 1996): Based on the results the test material can be considered to be moderately sensitive to ignition from electronic discharges when in the form of a dust cloud.

Powder Volume Resistivity - (Weaver, 1996): The test material has a powder volume resistivity at ambient relative humidity (relative humidity 42% , 21°C) of 2.2 X 10 E-12 Ωm. The test material has a powder volume resistivity at low relative humidity (relative humidity <10%, 19°C) 1.5 X 10 E-14 Ωm.

Charge Relaxation Time - (Weaver, 1996): Charge Relaxation Time (Ambient relative humidity 42%): 10.2 minutes; Charge Relaxation Time (Low relative humidity <10%): 2.54 hours.

Studies conducted on the  analogue substance Abacavir Succinate

Minimum Ignition Energy Measurement - (Weaver, 1996): Minimum Ignition Energy: 70 - 80 mJ. Based on the results the test material can be considered to have minimal sensitivity to ignition from electronic discharges when in the form of a dust cloud.

Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996): The minimum ignition temperature of dispersed dust was determined to be 460°C.

Powder Volume Resistivity - (Weaver, 1996): The test material has a powder volume resistivity at ambient relative humidity (relative humidity 43% , 23°C) of 4.0 X 10 E8 Ωm. The test material has a powder volume resistivity at low relative humidity (relative humidity <10%, 34°C) 3.3 X 10 E9 Ωm.

Charge Relaxation Time - (Weaver, 1996): The charge relaxation time of the test material at both ambient and low relative humidity is < 1 second.

Additional information

A number of physical-chemical studies have been carried out on both the substance of interest, Abacavir Glutarate, and the analogue materials Abacavir Hemisulphate and Abacavir Succinate.

The studies were conducted for risk assessment purposes for use in the workplace and transport. They are not conducted to OECD standard and in some cases are not GLP compliant.

Based on these obsversations, the studies cannot be considered to be reliable and are included here for information purposes only.

Study conducted on the substance of interest Abacavir Glutarate

Minimum Ignition Temperature (Layer) - (Gilmore, 2003)

The test was performed in accordance with SOP LP-08. The test was performed using a controlled hot plate and Pico Log data acquisition system. The SOP is based on IEC Standard 1241 -2 -1, Part 2.

Minimum ignition temperature (powder layer): No ignition or exotherm observed up to 400°C.

Studies conducted on the analogue substance Abacavir Hemisulphate

Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996):

The test was performed in accordance with IEC 1241-2-1 Electrical Apparatus for use in the presence of Combustible Dusts. Part 2. Method B.

Ignition produced bright, orange flames and no visible smoke and the Minimum ignition temperature of dispersed dust was determined to be 570°C.

Minimum Ignition Energy Measurement - (Weaver, 1996):

The test was performed in accordance with BS 5958: Part I (1991) or the German VDI organisation (Fortschritt-Berichte VDI, Reihe 3: Verfahrenstechnik Nr 134). The test was performed using a vertical tube apparatus.

Based on the results the test material can be considered to be moderately sensitive to ignition from electronic discharges when in the form of a dust cloud.

Powder Volume Resistivity - (Weaver, 1996):

Based on the test results the teat material can be considered to have a powder volume resistivity at ambient relative humidity of >10¹²

Ωm and a powder volume resistivity at low relative humidity of >10¹⁴Ωm and is therefore considered to be insulating.

Charge Relaxation Time - (Weaver, 1996):

A study carried out to establish the charge relaxation time of the test material produced the following conclusions:

Charge Relaxation Time (Ambient relative humidity 42%): 10.2 minutes

Charge Relaxation Time (Low relative humidity < 10%): 2.54 hours

Studies conducted on the analogue substance Abacavir Succinate

Minimum Ignition Energy Measurement - (Weaver, 1996):

The test was performed in accordance with BS 5958: Part I (1991). The test was performed using a vertical tube apparatus.

Minimum Ignition Energy: 70 - 80 mJ.

Based on the results the test material can be considered to have minimal sensitivity to ignition from electronic discharges when in the form of a dust cloud.

Minimum Ignition Temperature (Dust Cloud) - (Weaver, 1996):

The test was performed in accordance with IEC 1241-2-1 Electrical Apparatus for use in the presence of Combustible Dusts. Part 2. Method B.

Ignition produced a bright, orange flame and small quantities of grey smoke. The minimum ignition temperature of dispersed dust was determined to be 460°C.

Powder Volume Resistivity - (Weaver, 1996):

Based on the test results the teat material can be considered to have a powder volume resistivity at ambient relative humidity in the range of 10⁶Ωm and 10¹²Ωm and a powder volume resistivity at low relative humidity in the range of 10⁶Ωm and 10¹²Ωm

and is therefore considered to be borderline to being conductive.

Charge Relaxation Time - (Weaver, 1996):

A study carried out to establish the charge relaxation time of the test material produced the following conclusions:

Charge Relaxation Time (Ambient relative humidity 43%): < 1 second

Charge Relaxation Time (Low relative humidity < 10%): < 1 second