Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 203-564-8 | CAS number: 108-24-7
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Study period:
- Not reported
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: Non GLP, non guideline, animal experimental study. Notable limitations in design and reporting such that considered unreliable for endpoint.
Data source
Reference
- Reference Type:
- publication
- Title:
- Immediate Generalised Skin Reactions in Hypersensitive Guinea Pigs.
- Author:
- Jacobs JL
- Year:
- 1 940
- Bibliographic source:
- Proc. Soc. Exptl. Biol. Vol 43 pp 641
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Guinea pigs sensitised to citraconic acid and tested by scratching the skin with a 25% dioxane solution of acetic anhydride, usually at intervals of 2 weeks. No positive control.
- GLP compliance:
- no
- Type of study:
- other: Guinea pigs sensitised to citraconic acid and tested with acetic anhydride.
Test material
- Reference substance name:
- Acetic anhydride
- EC Number:
- 203-564-8
- EC Name:
- Acetic anhydride
- Cas Number:
- 108-24-7
- Molecular formula:
- C4H6O3
- IUPAC Name:
- acetyl acetate
- Details on test material:
- No data
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals and environmental conditions:
- Not reported.
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: Method described in previous publication
- Vehicle:
- other: 25% dioxane solution
Challenge
- Route:
- intradermal
- Vehicle:
- other: 25% dioxane solution
- No. of animals per dose:
- Not reported
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
Method previously reported - no details given
- Duration:
- Concentrations:
B. CHALLENGE EXPOSURE
- No. of exposures:
- Day(s) of challenge:
- Exposure period:
- Test groups:
- Control group:
- Site:
- Concentrations:
- Evaluation (hr after challenge):
OTHER:
Study design: in vivo (LLNA)
- No. of animals per dose:
- Not reported
Results and discussion
In vivo (non-LLNA)
Results
- Reading:
- other: not specified
- Group:
- test chemical
- Dose level:
- not reported
- Clinical observations:
- Extensive immediate wheal-and-erythema reactions, with subsidiary reactions in some cases.
- Remarks on result:
- other: Reading: other: not specified. Group: test group. Dose level: not reported. Clinical observations: Extensive immediate wheal-and-erythema reactions, with subsidiary reactions in some cases..
Applicant's summary and conclusion
- Interpretation of results:
- sensitising
- Remarks:
- Migrated information
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