Registration Dossier
Registration Dossier
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EC number: 200-679-5 | CAS number: 68-12-2
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP guideline study without analytical concentration verification
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Reference substance (positive control):
- no
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 13 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- yes
- Conclusions:
- EC50 = 13100 mg/L
- Executive summary:
Acute toxicity of DMF to Daphnia magna was examined in a static test according to OECD Guideline 202.
Results: EC50 = 13100 mg/L
Reference
Description of key information
EC50 (48 h) = 13100 mg/L for Daphnia magna (OECD Guideline 202, static, non-GLP).
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 13 100 mg/L
Additional information
The reported acute toxicity of DMF to Daphnia magna ranges from EC50(48h) >100 up to 14500 mg/L. The EC50 > 100 mg/L (BASF AG, 1992) following OECD Guideline 202 represents for formal reasons the lowest valid EC50 value. However, this value is not taken into account for the chemical safety assessment due to the fact that this was only a limit test. A more realistic value is given by a study conducted by Jarosz, T. (2008). This result (EC50 (48h) = 13100 mg/L) will be used in the risk assessment for N,N-dimethylformamide.
Additionally, a Daphnia magna study is conducted in accordance with US-EPA (1975) EPA-660/3-75-009 under static test conditions. Thereby EC50 were derived for an exposure duration of 24h and 48h: EC50 (24 h): 26300 mg/L; EC50 (48 h): 14500 mg/L
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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