2-ethylhexyl palmitate

Additional toxicological data

Administrative data

Endpoint:

additional toxicological information

Type of information:

experimental study

Adequacy of study:

disregarded due to major methodological deficiencies

Study period:

23 Apr - 26 May 1990

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Acceptable, well documented study report which meets basic scientific principles.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1990

Report date:

1990

Materials and methods

Type of study / information:

Comedogenicity potential of the test substance

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The study was performed to assess the comedogenicity potential of the test substance by repeated application to the external ear canal of the New Zealand White rabbit according to Kligman and Kwong (1979).

GLP compliance:

yes

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl palmitate

EC Number:

249-862-1

EC Name:

2-ethylhexyl palmitate

Cas Number:

29806-73-3

Molecular formula:

C24H48O2

IUPAC Name:

2-ethylhexyl palmitate

Details on test material:

- Name of test material (as cited in study report): 2-ethylhexyl palmitate
- Physical state: colourless liquid
- Analytical purity: no data
- Lot/batch No.: 950
- Storage condition of test material: room temperature

Results and discussion

Any other information on results incl. tables

Increased follicular keratosis (gredes 1 -2 on a scale of 0 -5) was noted in the treated ears. The hyperkeratosis became apparent in one treated ear after the first application, in one treated ear after the second application and in the remaining treated ear after the third application. A local irritating effect was observed by slight or well defined erythema or flaking of the epidermis, was noted in all treated ears during the study period.

Also slight to strong hyperkeratosis (grades 1 -3 on a scale of 0 -3) was noted in all treated ears. Slight hyperkeratosis (grade 1) were noted in one untreated control ear.