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Diss Factsheets
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EC number: 215-710-8 | CAS number: 1344-95-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
Link to relevant study record(s)
- Endpoint:
- bioaccumulation in aquatic species: invertebrate
- Data waiving:
- other justification
- Justification for data waiving:
- the study does not need to be conducted because the substance has a low potential to cross biological membranes
- other:
- Justification for type of information:
- Silicic acid, calcium salt is an inorganic solid which is insoluble in n-octanol. Due to its inherent physicochemical properties bioaccumulation is not expected.
Log Kow result are not available due to the inorganic nature of the substance.
As the substance is poorly soluble, low concentrations are expected in the aquatic compartment. Low quantities which might be taken up are considered to be not bioavailable. Absorbed Si levels are known to be rapidly excreted in urine and faeces. Thus,calcium silicate contains no bioaccumulation potential.
After oral ingestion, there is no accumulation of synthetic amorphous silica in body tissues. Upon cessation of exposure rapid elimination occurs. Intestinal resorption appears to be insignificant in animals and humans, the small apparent increases in the urine output of human volunteers were remarkably low as compared with the high dose of 2500 mg SiO2 applied subcutaneously are subjected to rapid dissolution and removal.
The inorganic nature of calcium silicate precludes the possibility of metabolic by-products.
There are no concerns regarding toxic effects in any of the (eco-)toxicological studies, short or long term, carried out on the test substance and any analogues. This would indicate that the substance is unlikely to bioaccumulate within biological tissues.
These include
EC10 or NOEC ≥ 0.01 mg/L for marine / freshwater organisms (long-term toxicity)
The substance is not classified as carcinogenic (category 1 or 2), mutagenic (category 1 or 2), or toxic for reproduction (category 1, 2 or 3) according to Directive 67/548/EEC or carcinogenic
(category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008
There is no other evidence of chronic toxicity, as identified by the classifications T, R48 or Xn, R48 according to Directive 67/548/EEC or specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to Regulation EC No 1272/2008 - Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
- Reason / purpose for cross-reference:
- data waiving: supporting information
Reference
Description of key information
Silicic acid, calcium salt is an inorganic solid which is insoluble in n-octanol. Due to its inherent physicochemical properties bioaccumulation is not expected.
Log Kow result are not available due to the inorganic nature of the substance.
As the substance is poorly soluble, low concentrations are expected in the aquatic compartment. Low quantities which might be taken up are considered to be not bioavailable. Absorbed Si levels are known to be rapidly excreted in urine and faeces. Thus,calcium silicate contains no bioaccumulation potential.
After oral ingestion, there is no accumulation of synthetic amorphous silica in body tissues. Upon cessation of exposure rapid elimination occurs. Intestinal resorption appears to be insignificant in animals and humans, the small apparent increases in the urine output of human volunteers were remarkably low as compared with the high dose of 2500 mg SiO2 applied subcutaneously are subjected to rapid dissolution and removal.
The inorganic nature of calcium silicate precludes the possibility of metabolic by-products.
There are no concerns regarding toxic effects in any of the (eco-)toxicological studies, short or long term, carried out on the test substance and any analogues. This would indicate that the substance is unlikely to bioaccumulate within biological tissues.
These include
EC10 or NOEC ≥ 0.01 mg/L for marine / freshwater organisms (long-term toxicity)
The substance is not classified as carcinogenic (category 1 or 2), mutagenic (category 1 or 2), or toxic for reproduction (category 1, 2 or 3) according to Directive 67/548/EEC or carcinogenic
(category 1A or 1B), germ cell mutagenic (category 1A or 1B), or toxic for reproduction (category 1A, 1B or 2) according to Regulation EC No 1272/2008
There is no other evidence of chronic toxicity, as identified by the classifications T, R48 or Xn, R48 according to Directive 67/548/EEC or specific target organ toxicity after repeated exposure (STOT RE category 1 or 2) according to Regulation EC No 1272/2008
Key value for chemical safety assessment
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.