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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Skin sensitisation

Currently viewing:

Administrative data

Endpoint:
skin sensitisation
Remarks:
in vivo
Type of information:
experimental study
Adequacy of study:
supporting study
Reliability:
3 (not reliable)
Rationale for reliability incl. deficiencies:
other: Documentation insufficient for assessment

Data source

Reference
Reference Type:
publication
Title:
Experimental Carcinogenicity and Acute Toxicity of Representative Epoxides
Author:
Weil C S et al.
Year:
1963
Bibliographic source:
Amer Industr Hyg Ass J 24:305-325.

Materials and methods

Principles of method if other than guideline:
Sensitization of guinea pigs was determined by a technique consisting of eight intracutaneous injections (three per week on alternate days) of 0.1 ml of the diluted epoxy materials. A three-week icubation period was followed by a challenge dose and examinations for possible sensitization reactions were made 24 and 48 hours thereafter.
GLP compliance:
no
Remarks:
Study performed before implementation of GLP
Type of study:
not specified

Test material

Constituent 1
Chemical structure
Reference substance name:
(epoxyethyl)benzene
EC Number:
202-476-7
EC Name:
(epoxyethyl)benzene
Cas Number:
96-09-3
Molecular formula:
C8H8O
IUPAC Name:
2-phenyloxirane

In vivo test system

Test animals

Species:
guinea pig
Strain:
not specified
Sex:
not specified

Study design: in vivo (non-LLNA)

Inductionopen allclose all
Route:
intradermal
Vehicle:
no data
Concentration / amount:
no data
Challengeopen allclose all
Route:
intradermal
Vehicle:
no data
Concentration / amount:
no data
No. of animals per dose:
11
Positive control substance(s):
not specified

Results and discussion

Applicant's summary and conclusion

Interpretation of results:
sensitising
Remarks:
Migrated information