Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 202-876-1 | CAS number: 100-66-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Several publications dealt with absorption, metabolism and glucuronidation are available. In most of these publications several food additives were examined.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 80
Additional information
Absorption: Bray et al.,1952 publication showed in a metabolism study performed in rabbits after oral administration (gavage) that anisole (0.5 g/kg) was mainly absorbed after oral route exposure. 80% of the administered dose were absorbed 24 hours after exposure.
In Fritsch et al., 1974 study in which an in situ perfusion in rats was used to study gastro-intestinal absorption, anisole was largely absorbed from the digestive tract by a mechanism of passive diffusion. 64.06 % of the dose were absorbed 120 minutes after perfusion (2 mg/L) by the gastric tract and 76.70% of the administered dose by the intestinal tract in the same conditions.
Distribution: No specific study on anisole distribution is available. However, based on the studies describing anisole absorption and metabolism, it has been showed that anisole is distributed via blood and the substance has been found in olfactory mucosa, olfactory bulb and liver.
Metabolism: In the study describing metabolism (Bray et al., 1952), the only metabolites observed in rabbit after oral exposure (gavage) are phenols excreted either free or as O-conjugates for approximately 80% of the administered dose. The main metabolite of anisole identified was p-methoxyphenol. Anisole metabolism involves the formation of a center for conjugation by hydroxylation, with conjugation of the resultant phenolic ethers with glucuronic and sulphuric acids.
In the last publication, the glucuronidation of a series of odorant molecules by homogenates prepared either with rat olfactory mucosa, olfactory bulb or brain was studied. For anisole the most activity was demonstrated in the olfactory mucosa, while the activity was very low in the olfatory bulb and not detected in the brain.
Excretion: In the studies describing the metabolism in the caecal flora of the rat (Fritsch et al;,1975a), and the absorption in the digestive tract (Fritsch et al.,1975b), it was demonstrated that anisole was completely absorbed and excreted. Anisole via metabolites is mainly excreted in urine and excretion by respiratory tract was not detected in rabbit after oral exposure.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.