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EC number: 293-054-1 | CAS number: 91051-05-7
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
No effects up to the limit of water solubility.
Key value for chemical safety assessment
Additional information
There are no studies available on the toxicity of Fatty acids essential, Et esters (CAS 91051 -05 -7) to aquatic invertebrates. The assessment was therefore based on studies conducted with the structurally most similar category members, for which data is available, Isopropyl myristate (CAS 110-27-0) and 2-ethylhexyl oleate (CAS 26399-02-0), as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach. Further justification is given within the endpoint summary 6.1 and within the category justification section 13. In this case of read-across, the best suited (highest degree of structural similarity, nearest physico-chemical properties) read-across substance was entered into IUCLID. Nevertheless, as can be seen in the data matrix of the category justification in Section 13, all reliable data in the category support the hazard assessment for this endpoint, by showing a consistent pattern of results.
In the first key study with Daphnia magna, three different treatments of Isopropyl myristate (CAS 110 -27 -0) were applied for the test performance according to EU Method C.2 under GLP conditions (Küch 1995). Method 1: limit test 100 mg/L test substance and 5 min. ultrasonic treatment; Method 2: limit test 100 mg/L, 24 h stirring and removal of undissolved test substance via filtration through glass fibre filter; Method 3: 3-5 times saturation, 24 h stirring. In all tests animals were swimming at the water surface. Furthermore, using method 1, an oily film was present. Method 1 (limit test without substance separation) resulted in an EC50 < 100 mg/L (nominal), whereas in method 2 and 3 (both tests with substance separation) the EC50 was established as greater than the water solubility. In conclusion: the results indicate that physical effects may occur in the presence of undissolved test material.
The second key study investigated the effects of 2-ethylhexyl oleate (CAS 26399-02-0) to the freshwater invertebrate Daphnia magna (Küch and Wierich 1995). The study was performed according to the EU-method C.2 considering the VCI concept draft for the acute testing of poorly soluble substances from 1994-01-31 for 48 h. The first approach without removal of the insoluble particles resulted in immobilisation rates between 0 and 100% (mean: 25%). After removal of insoluble particles (filtration) no effects to Daphnia magna were observed. Thus, it can be stated that the insoluble particles of the test substance resulted in negative physical effects to the test species (e.g. agglutination of gills). No effects in the range of water solubility were observed. This resulted in an EC50 (48h) > 100 mg/L (nominal).
A marine supporting study, read-across from Isopropyl oleate (CAS 112-11-8), on the species Crangon crangon resulted in a LC50(96h) value >8500 mg/L.
Thus, based on the above mentioned result, and due to the structural and profile similarities of the substances, as are explained with in the overall endpoint summary 6.1 it can be concluded that no toxicological effects on aquatic invertebrates are expected up to the limit of water solubility for Fatty acids, essential, Et esters (CAS 91051-05-7).
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