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Diss Factsheets
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EC number: 200-812-7 | CAS number: 74-82-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Epidemiological data
Administrative data
- Endpoint:
- epidemiological data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Non-GLP, Non-guideline human population study, fully adequate for assessment
Data source
Reference
- Reference Type:
- publication
- Title:
- Breath methane and large bowel cancer risk in contrasting African populations
- Author:
- Segal I, et al.
- Year:
- 1 988
- Bibliographic source:
- Gut, 29, 608-613
Materials and methods
- Study type:
- cohort study (retrospective)
- Endpoint addressed:
- not applicable
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Breath methane was measured in 1016 people from four populations with different risks of bowel cancer and other colonic diseases
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Reference substance 003
- Cas Number:
- 74-82-8
- Molecular formula:
- C H4
- Reference substance name:
- 74-82-0
- IUPAC Name:
- 74-82-0
- Details on test material:
- Methane was sampled from exhaled breath
Constituent 1
Constituent 2
Method
- Type of population:
- other: 1016 people from four populations resident in South Africa with different risks of bowel cancer and other colonic disease (rural black, urban black, white, Indian)
- Ethical approval:
- not specified
- Details on study design:
- Breath was sampled using a Wiggins end expiratory breath sampler. Methane concentration was determined by gas chromatography using a Pye Unicam PU-4500 equipped with a hydrogen ionisation detector.
- Exposure assessment:
- measured
- Details on exposure:
- See above
- Statistical methods:
- No data
Results and discussion
- Results:
- Highly significant differences in the proportion of subjects with detectable methane in breath were found; % producers - rural black 84, urban black 72, white 52, Indian 41.Bowel cancer risk determined from a variety of sources was lowest in rural blacks, greatest in whites, with intermediate rates for urban blacks and Indians.
Applicant's summary and conclusion
- Conclusions:
- Methane production in the human colon shows significant interethnic differences but shows no relationship to bowel cancer risk.
- Executive summary:
Breath methane was measured in 1016 people from four populations with different risks of bowel cancer and other colonic diseases.
Highly significant differences in the proportion of subjects with detectable methane in breath were found; % producers - rural black 84, urban black 72, white 52, Indian 41. Bowel cancer risk determined from a varietary of sources was lowest in rural blacks, greatest in whites, with intermediate rates for urban blacks and Indians. Methane production in the human colon shows significant interethnic differences but shows no relationship to bowel cancer risk in these populations.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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