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Diss Factsheets
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EC number: 201-327-3 | CAS number: 81-13-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Aquatic toxicity
Short-term toxicity to fish
In the key study the acute toxicity of D-Panthenol for fish was estimated by continuous exposure of rainbow trouts for 96 hours, according to the GLP Standard Operation Procedure PSU FT1991. Following an acclimation and adaptation period, groups of ten trouts were exposed under controlled conditions, using a static test system, to three different concentrations of the test compound. As a control, a group of ten fish was exposed to normal city water. Fish were observed daily and behavior and mortality were recorded. Based on the 96-hour acute toxicity study, the NOEC (no observed effect concentration) of D-Panthenol for rainbow trouts (Salmo gairdneri) is > 1000 mg/l.
In a supporting study the short term toxicity to fish was assessed in a study performed in golden orfe equivalent or similar to OECD Guideline 203. Based on the results obtained from testing the EC50 (96 h) was determined to be > 10000 mg/L.
Short-term toxicity to aquatic invertebrates
The short term toxicity of the substance to aquatic invertebrates was tested in daphnia magna in a study performed according to OECD Guideline 202, Part I, 1984. Based on the results obtained from testing the EC50 (48 h) was determined to be > 100 mg/L. No mortalities or any other effects which could be related to the test item. Thus, the substance was considered to be practically non toxic to aquatic invertebrates.
Toxicity to aquatic algae and cyanobacteria
The short term toxicity of the substance to aquatic algae and cyanobacteria was tested in Scenedesmus subspicatus (new name: Desmodesmus subspicatus) in a study performed according to OECD Guideline 201, 1984. Based on the results obtained from testing the EC50 (72 h) was determined to be > 100 mg/L. No mortalities or any other effects which could be related to the test item were noted during the course of the study. Thus, the substance was considered to be practically non toxic to aquatic algae and cyanobacteria.
Toxicity to microorganisms
The toxicity to microorganisms was assessed in a study performed in Pseudomonas putida acoording to DIN 38412, part 8. Based on the results obtained from testing the EC50 (17 h) was determined to be > 10000 mg/L.
In a supporting study performed according to ISO 8192 (Test for Inhibition of Oxygen Consumption by Activated Sludge), the EC20 (30 min) was determined to be > 800 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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