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EC number: 204-010-8 | CAS number: 112-85-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Studies on soil toxicity of docosanoic acid (CAS 112-85-6) to terrestrial organisms are not available.
The target substance is characterized by a low water solubility (0.016 mg/L at 25 °C), a high potential for adsorption to organic soil particles (log Koc = 5.64, KOCWIN v2.00) and ready biodegradability.
All reliable aquatic acute (fish, invertebrates, algae) and aquatic chronic data (fish, invertebrates, algae) for the target substance and suitable source substances indicate no effects up to the water solubility limit. Thus, as the water solubility of the substance is < 1 mg/L (0.016 mg/L at 25 °C)) and no long-term effects to aquatic organisms were observed up to the substance solubility limit, this fact can be used as part of a Weight-of-Evidence argument to waive the data requirement of Annex X for terrestrial toxicity according to chapter R. 7c of the ‘Guidance on information requirements and chemical safety assessment' (ECHA, 2017).
In addition, based on the readily biodegradability of the substance, docosanoic acid is expected to be eliminated in sewage treatment plant to a high extent. As mentioned in the Guidance on Information Requirements and Chemical Safety Assessment, Chapter R.7b (ECHA, 2017), the ready biodegradability of a substance can be an indication of rapid and ultimate degradation in most environments, including biological sewage treatment plants (STP). Thus, the substance will be extensively removed by microorganisms in biological sewage treatment plants. Moreover, degradation studies cited in the Draft Assessment Report (DAR, Volume 1 and 3, 2008) show DT50 values of 1.5 to – 3 days for Fatty Acids (C7-C20), indicating rapid primary degradation of fatty acids by microbial organisms in the soil environment. Besides, due to the high adsorption potential of the substance (log Koc = 5.64, KOCWIN v2.00), a removal from the water column to a significant degree by adsorption to sewage sludge can be expected (Guidance on information requirements and chemical safety assessment, Chapter R.7b, (ECHA, 2017)). Thus, discharged concentrations of the substance into the soil compartment are likely to be negligible. Overall, the bioavailability of docosanoic acid (CAS 112-85-6) in the soil environment is expected to be low, which reduces the probability of exposure, in particular long-term exposure, of soil organisms in general.
Furthermore, Fatty acids generally occur naturally in soils and are part of physiological pathways. Fatty acids are used by soil organisms as an energy source and for anabolic processes as well. According to Draft Assessment Report (DAR), low toxicity of a fatty acid formulation was demonstrated in several tests on soil macroorganisms, terrestrial non-target arthropods and terrestrial plants (DAR, Volume 1, 2008). Thus, toxic effects to soil organisms caused by docosanoic acid (CAS 112-85-6) are negligible.
In conclusion, due to the following reasons no study on the effects on terrestrial organisms need to be conducted for docosanoic acid (CAS 112-85-6):
- absence of long-term effects in aquatic organisms up to the water solubility limit
- a rapid primary degradation of fatty acids by microbial organisms in the soil environment
- a removal from the water column to a significant degree by adsorption to sewage sludge
- a low bioavailability
- fatty acids are part of the physiological pathway
- low toxicity demonstrated for fatty acid formulation
References:
Draft Assessment Report (DAR) for Fatty Acids (C7-C29) (Volume 1, August 2008)
Draft Assessment Report (DAR) for Fatty Acids (C7-C29) (Volume 3, Annex B, Part 4, B.8, August 2008)
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