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EC number: 202-873-5 | CAS number: 100-63-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Data on the acute toxicity of phenylhydrazine was available, including oral, dermal and inhalative acute toxicity data.
Key value for chemical safety assessment
Acute toxicity: via oral route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 80 mg/kg bw
Acute toxicity: via inhalation route
Endpoint conclusion
- Dose descriptor:
- LC50
- Value:
- 2 093 mg/m³ air
Acute toxicity: via dermal route
Endpoint conclusion
- Dose descriptor:
- LD50
- Value:
- 380 mg/kg bw
Additional information
Non-human data:
Acute toxicity data was available for different species. After oral administration oral LD50 values in the range 80–250 mg/kg bw were reported for the rat, mouse, guinea-pig, dog, and rabbit (Ekshtat, 1965; Pham, 1979). Clinical signs reported were motor excitation and tonic/clonic spasms.
Acute dermal toxicity studies in rabbits revealed 20–30 % mortality after exposure to 380 mg phenylhydrazine/kg body weight for 24 h, although no deaths occurred in rats at this dose, i.e. LD50 greater than 380 mg/kg bw (Derelanko et al., 1987). The toxic effects were characterized by destruction of red blood cells, causing a reduction in erythrocyte count, increased reticulocyte count, methaemoglobin formation, and the formation of Heinz bodies, and a cyanotic external appearance may develop. Enlargement and dark coloration of the spleen were also reported, effects considered to be secondary to the erythrocyte damage.
In an acute inhalation study LC50 values of 2745 mg/m3 (610 ppm) for rats and 2093 mg/m3 (465 ppm) for mice (Pham, 1979).
Phenylhydrazine is toxic by intraperitoneal administration, and LD50 values in the range 170-200 mg/kg body weight for i.p. administration in the mouse were reported (Parodi et al., 1981; Kostenko et al., 1985).
Human data:
Occupational exposure data revealed some systematic toxicity effects following dermal contact to phenylhydrazine in liquid preparation. Systemic toxicity developed in humans after dermal exposure to liquid phenylhydrazine, despite immediate attempts to reduce exposure by removal of contaminated clothing and washing of skin (Schuckmann, 1969). Toxicity was manifest by damage to red blood cells, in one case resulting in haemolytic jaundice. No such systemic effects were reported in two cases of skin contamination with solid phenylhydrazine hydrochloride.
Justification for classification or non-classification
Oral:
Based on Directive 67/548/EEC (DSD) and Regulation 1272/2008/EC (CLP), phenylhydrazine was classified as toxic if swallowed (T, R25; cat 3, H301).
Inhalation:
Based on Directive 67/548/EC (DSD) and Regulation 1272/2008/EC (CLP), phenylhydrazine was classified as toxic if inhaled (T, R23; cat 3, H331).
Dermal:
Based on Directive 67/548/EC (DSD) and Regulation 1272/2008/EC (CLP), phenylhydrazine was classified as toxic in contact with skin (T, R24; cat 3, H311).
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