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Diss Factsheets
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EC number: 203-820-9 | CAS number: 110-97-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Carcinogenicity
Administrative data
Description of key information
In a limited 94-week carcinogenicity study, no differences in tumor incidence were observed between controls and male rats administered 1% DIPA via the diet. In addition, the substance is not mutagenic and no hyperplasia and/or pre-neoplastic lesions were observed in the oral semichronic repeated dose toxicity study.
Key value for chemical safety assessment
Mode of Action Analysis / Human Relevance Framework
No information available.
Justification for classification or non-classification
Based on the results of a 94-week carcinogenicity study with 1% DIPA in the diet, the absence of hyperplasia and/or pre-neoplastic lesions in the oral semichronic repeated dose toxicity study and the negative in vitro genotoxicity studies, DIPA is considered to be non-carcinogenic; therefore classification according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008 is not warranted.
Additional information
A 94-week dietary study with 0 or 1% DIPA in the feed was conducted using 20 male Wistar rats (Yamamoto et al., 1989). Sixteen of twenty animals survived in the treatment group. Intakes of feed and water were evaluated daily and were constant throughout the study. No treatment-related effects on body weight were observed. Histopathological examination was conducted for all major organs with no significant differences between tumor incidence in controls or treated groups reported.
However, exposure by male Wistar rats to both 1% DIPA in the diet plus 0.15 or 0.3% sodium nitrite in drinking water resulted in nasal and lung tumors with incidences of 74 and 58% in rats given 1% DIPA and 0.3% sodium nitirite. N-nitroso compounds [N-nitroso-diisopropanolamine at 24, 34 and 80 weeks; N-nitroso(2-hyroxypropyl)(2-oxopropyl)amine at 24 and 34 weeks were also excreted in urine after exposure to DIPA and 0.3% sodium nitrite (Yamamoto et al.,1989). Only limited details are available for this study.
The substance is not mutagenic and no hyperplasia and/or pre-neoplastic lesions were observed in the oral semichronic repeated dose toxicity study with DIPA.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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