Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-820-9 | CAS number: 110-97-4
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
With high probability acutely not harmful to fish.
The toxicity of di-isopropanolamine to fish was tested in a study conducted in compliance with OECD test guideline 203, using Danio rerio as test species; the 96-h LC50 was determined to be 1466 mg/l in non-neutralized test solutions (nominal; calculated geometrical mean value; LC0 = 1000 mg/L, LC100 = 2150 mg/L). No difference regarding the toxicity of the substance was observed when replicates with pH adjusted test concentrations were used (BASF AG, 1995). This result is supported by a study conducted according to German Standard DIN 38412, part 15 testing the toxicity of the substance to Leuciscus idus in a static test system (BASF AG, 1987).
Short-term toxicity to aquatic invertebrates:
With high probability not acutely harmful to aquatic invertebrates.
The toxicity of di-isopropanolamine to Daphnia magna was determined in a static test conducted according to guideline 79/831/EEC, C.2. After 48 hours an EC50 of 277.7 mg/l was determined (nominal; not pH-adjusted; BASF AG, 1987).
Toxicity to aquatic algae and plants:
With high probability acutely not harmful to aquatic algae and cyanobacteria.
In the key study performed according to German standard DIN 38412, part 9 Scenedesmus subspicatus was exposed to di-isopropanolamine for 72 hours. At termination of the study an ErC50 of 339 mg/l was determined (72 -h ErC10 = 219 mg/L; BASF AG, 1988).
In contrast, an EC50 of 74 mg/l based on the growth rate of Selenastrum capricornutum was determined in a second study after 72 hours (Nagpal, 2003). However, these data are insufficient for the assessment, as no details on test performance are given.
Furthermore, Eide-Haugmo et al. (2012/2009) performed a guideline study according to ISO 10253 with the marine algae Skeletonema costatum. After 72 hours an ErC50 of 240.0 mg/L was determined.
Toxicity to microorganisms:
The inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
In a test performed according to ISO 8192 B, activated sludge (industrial) was exposed to di-isopropanolamine for 30 minutes and an EC20 of > 1995 mg/l was determined (BASF AG, 1981). In a test on Pseudomonas putida a toxicity threshold concentration of 15000 mg/l (equivalent to EC3) was determined (BASF AG, 1988).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
