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EC number: 605-318-9 | CAS number: 163206-31-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 998
- Report date:
- 1998
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Version / remarks:
- (1996)
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- acute toxic class method
- Limit test:
- yes
Test material
- Reference substance name:
- N-(6-{3-[6-(3-{6-[3,5-bis({6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl})-2,4,6-trioxo-1,3,5-triazinan-1-yl]hexyl}-5-{6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl}-2,4,6-trioxo-1,3,5-triazinan-1-yl)hexyl]-5-{6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl}-2,4,6-trioxo-1,3,5-triazinan-1-yl}hexyl)-3,5-dimethyl-1H-pyrazole-1-carboxamide; N-[6-(3-{6-[3,5-bis({6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl})-2,4,6-trioxo-1,3,5-triazinan-1-yl]hexyl}-5-{6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl}-2,4,6-trioxo-1,3,5-triazinan-1-yl)hexyl]-3,5-dimethyl-1H-pyrazole-1-carboxamide; N-{6-[3,5-bis({6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl})-2,4,6-trioxo-1,3,5-triazinan-1-yl]hexyl}-3,5-dimethyl-1H-pyrazole-1-carboxamide
- EC Number:
- 605-318-9
- Cas Number:
- 163206-31-3
- Molecular formula:
- Not applicable (UVCB substance)
- IUPAC Name:
- N-(6-{3-[6-(3-{6-[3,5-bis({6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl})-2,4,6-trioxo-1,3,5-triazinan-1-yl]hexyl}-5-{6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl}-2,4,6-trioxo-1,3,5-triazinan-1-yl)hexyl]-5-{6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl}-2,4,6-trioxo-1,3,5-triazinan-1-yl}hexyl)-3,5-dimethyl-1H-pyrazole-1-carboxamide; N-[6-(3-{6-[3,5-bis({6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl})-2,4,6-trioxo-1,3,5-triazinan-1-yl]hexyl}-5-{6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl}-2,4,6-trioxo-1,3,5-triazinan-1-yl)hexyl]-3,5-dimethyl-1H-pyrazole-1-carboxamide; N-{6-[3,5-bis({6-[(3,5-dimethyl-1H-pyrazole-1-carbonyl)amino]hexyl})-2,4,6-trioxo-1,3,5-triazinan-1-yl]hexyl}-3,5-dimethyl-1H-pyrazole-1-carboxamide
- Details on test material:
- The test substance was tested in solution approx. in 75 % in 2−Methoxy−1−methylethylacetate/Solventnaphtha 100 (8:17)
Appearance: colourless to yellowish liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Strain: Hsd Cpb:WU, SPF-bred
- Source: Harlan Winkelmann, Borchen, Germany
- Age at study initiation: 7-8 weeks old
- Weight at study initiation: mean weight 199 g for males and 170 g for females
- Fasting period before study: yes, from 16 hours (over night) prior to at least 4 hours after application
- Housing: in goups of 3 animals in Makrolon® Type-III cages on low-dust wood granules
- Diet and Water: ad libitum
- Acclimation period: at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 2
- Humidity (%): 55 ± 5
- Air changes (per hr): 15 to 20
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- polyethylene glycol
- Details on oral exposure:
- Application volume: 10 mL/kg bw
The test substance was formulated in the application vehicle (polyethylene glycol 400) immediately prior to treatment. - Doses:
- 2000 mg/kg bw test item, which is 75 % in solvent. Thus, based on the active ingredient the dose was 1500 mg/kg bw.
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of administration, and at least once daily during the observation period.
- Frequency of weighing: directly before administration, after one week and at the end of the observation period or after death.
- Necropsy of survivors performed: yes - Statistics:
- Statistical evaluation of the data related to body weights was performed using SAS® routines. The variables are described by sex, dose group and date using appropriate measures of central tendency (mean) and general variability (standard derivation). An estimation of the median lethal dose (LD50) on the basis of the flow charts given in the guideline was done.
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 1 500 mg/kg bw
- Based on:
- act. ingr.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 75 % substance in solvent
- Mortality:
- No animal died after administration of the substance.
- Clinical signs:
- other: After administration of the substance no clinical signs were observed.
- Gross pathology:
- None of the animals sacrificed at the end of study showed any noticeable gross pathological findings.
- Other findings:
- None
Applicant's summary and conclusion
- Executive summary:
An acute oral toxicity study according to OECD TG 423 was conducted with a limit dose of 2000 mg/kg test item administered to 3 male and 3 female rats. The content of the substance in the test item was 75 %, therefore the actual limit dose was 1500 mg/kg bw based on active ingredient.
No animal died in the course of the study and no clinical signs were observed after administration of the test item. Body weight development was not affected. The animals sacrificed at the end of study showed no noticeable gross pathological findings. The LD50 was estimated to be > 2000 mg/kg bw for the test item, correlating to > 1500 mg/kg bw for the active ingredient.
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